1. GPCR/G Protein
    Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. CXCR
    Drug Metabolite
    Endogenous Metabolite
  3. Nicotinamide N-oxide

Nicotinamide N-oxide 

Cat. No.: HY-101407 Purity: 99.93%
Handling Instructions

Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

For research use only. We do not sell to patients.

Nicotinamide N-oxide Chemical Structure

Nicotinamide N-oxide Chemical Structure

CAS No. : 1986-81-8

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Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
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100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
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Description

Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

IC50 & Target

CXCR2

 

Human Endogenous Metabolite

 

In Vitro

Nicotinamide is one of the forms of vitamin B3. It is a precursor for nicotinamide adenine dinucleotide, which is best known as an electron carrier in oxidative phosphorylation and as a cofactor for many dehydrogenases. It is metabolized through two enzymatic systems. The first system starts with the methylation of nicotinamide by nicotinamide N-methyltransferase, which can subsequently be oxidized by aldehyde oxidase. The second enzymatic system oxidizes nicotinamide to nicotinamide N-oxide[1]. A series of nicotinamide N-oxides is synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Compound 1 has demonstrated potent inhibition of neutrophil chemotaxis (IC50=10 nM). Compound 2 is a selective antagonist of IL-8 binding (IC50=110 nM) and potent inhibitor of neutrophil chemotaxis (IC50=170 nM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

138.12

Formula

C₆H₆N₂O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 20 mg/mL (144.80 mM; Need ultrasonic)

DMSO : 10 mg/mL (72.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.2401 mL 36.2004 mL 72.4008 mL
5 mM 1.4480 mL 7.2401 mL 14.4802 mL
10 mM 0.7240 mL 3.6200 mL 7.2401 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (7.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (7.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Nicotinamide N-oxide
Cat. No.:
HY-101407
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