O-Desmethyl gefitinib-d₈

製品番号: HY-100064S 純度: 99.84%: Data Sheet SDS COA 取扱説明書
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O-Desmethyl gefitinib-d₈ is a deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC₅₀ of 36 nM in subcellular assays.

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O-Desmethyl gefitinib-d₈ 構造式

CAS 番号 : 2748500-39-0

容量	価格（税別）	在庫状況	数量
1 mg	$400	お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
5 mg	$1000	お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
10 mg		お問い合わせ
50 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of O-Desmethyl gefitinib-d₈:

O-Desmethyl gefitinib 在庫あり

EGFR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC₅₀ & Target

IC50: 36 nM (EGFR)^[2]

分子量

440.93

分子式

C₂₁H₁₄D₈ClFN₄O₃

CAS 番号

2748500-39-0

Unlabeled CAS

847949-49-9

Appearance

Solid

Color

White to off-white

SMILES

OC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN4C([2H])([2H])C([2H])([2H])OC([2H])([2H])C4([2H])[2H]

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (226.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2679 mL	11.3397 mL	22.6793 mL
5 mM	0.4536 mL	2.2679 mL	4.5359 mL
10 mM	0.2268 mL	1.1340 mL	2.2679 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.84%

Select Batch:

データシート (276 KB) SDS (252 KB)

COA (254 KB) HNMR (222 KB) LCMS (161 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Kobayashi H, et al. Effects of polymorphisms in CYP2D6 and ABC transporters and side effects induced by gefitinib on the pharmacokinetics of the gefitinib metabolite, O-desmethyl gefitinib. Med Oncol. 2016 Jun;33(6):57. [Content Brief]

[2]. McKillop D, et al. Minimal contribution of desmethyl-gefitinib, the major human plasma metabolite of gefitinib, to epidermal growth factor receptor (EGFR)-mediated tumour growth inhibition. Xenobiotica. 2006 Jan;36(1):29-39. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2679 mL	11.3397 mL	22.6793 mL	56.6983 mL
	5 mM	0.4536 mL	2.2679 mL	4.5359 mL	11.3397 mL
	10 mM	0.2268 mL	1.1340 mL	2.2679 mL	5.6698 mL
	15 mM	0.1512 mL	0.7560 mL	1.5120 mL	3.7799 mL
	20 mM	0.1134 mL	0.5670 mL	1.1340 mL	2.8349 mL
	25 mM	0.0907 mL	0.4536 mL	0.9072 mL	2.2679 mL
	30 mM	0.0756 mL	0.3780 mL	0.7560 mL	1.8899 mL
	40 mM	0.0567 mL	0.2835 mL	0.5670 mL	1.4175 mL
	50 mM	0.0454 mL	0.2268 mL	0.4536 mL	1.1340 mL
	60 mM	0.0378 mL	0.1890 mL	0.3780 mL	0.9450 mL
	80 mM	0.0283 mL	0.1417 mL	0.2835 mL	0.7087 mL
	100 mM	0.0227 mL	0.1134 mL	0.2268 mL	0.5670 mL