O-Desmethyl gefitinib-d₈

Cat. No.: HY-100064S Pureza: 99.84%: Ficha de datos
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O-Desmethyl gefitinib-d₈ is a deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC₅₀ of 36 nM in subcellular assays.

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O-Desmethyl gefitinib-d₈ Estructura química

No. CAS : 2748500-39-0

Tamaño	Stock	Cantidad
1 mg	Obtener un presupuesto 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
5 mg	Obtener un presupuesto 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
10 mg	Obtener un presupuesto
50 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

Other Forms of O-Desmethyl gefitinib-d₈:

O-Desmethyl gefitinib In-stock

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas EGFR:

Ver todas las isoformas

EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC₅₀ & Target

IC50: 36 nM (EGFR)^[2]

Peso molecular

440.93

Fòrmula

C₂₁H₁₄D₈ClFN₄O₃

No. CAS

2748500-39-0

Unlabeled CAS

847949-49-9

Appearance

Solid

Color

White to off-white

SMILES

OC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN4C([2H])([2H])C([2H])([2H])OC([2H])([2H])C4([2H])[2H]

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (226.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2679 mL	11.3397 mL	22.6793 mL
5 mM	0.4536 mL	2.2679 mL	4.5359 mL
10 mM	0.2268 mL	1.1340 mL	2.2679 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.84%

Select Batch:

Ficha de datos (276 KB) SDS (252 KB)

COA (254 KB) HNMR (222 KB) LCMS (161 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Kobayashi H, et al. Effects of polymorphisms in CYP2D6 and ABC transporters and side effects induced by gefitinib on the pharmacokinetics of the gefitinib metabolite, O-desmethyl gefitinib. Med Oncol. 2016 Jun;33(6):57. [Content Brief]

[2]. McKillop D, et al. Minimal contribution of desmethyl-gefitinib, the major human plasma metabolite of gefitinib, to epidermal growth factor receptor (EGFR)-mediated tumour growth inhibition. Xenobiotica. 2006 Jan;36(1):29-39. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2679 mL	11.3397 mL	22.6793 mL	56.6983 mL
	5 mM	0.4536 mL	2.2679 mL	4.5359 mL	11.3397 mL
	10 mM	0.2268 mL	1.1340 mL	2.2679 mL	5.6698 mL
	15 mM	0.1512 mL	0.7560 mL	1.5120 mL	3.7799 mL
	20 mM	0.1134 mL	0.5670 mL	1.1340 mL	2.8349 mL
	25 mM	0.0907 mL	0.4536 mL	0.9072 mL	2.2679 mL
	30 mM	0.0756 mL	0.3780 mL	0.7560 mL	1.8899 mL
	40 mM	0.0567 mL	0.2835 mL	0.5670 mL	1.4175 mL
	50 mM	0.0454 mL	0.2268 mL	0.4536 mL	1.1340 mL
	60 mM	0.0378 mL	0.1890 mL	0.3780 mL	0.9450 mL
	80 mM	0.0283 mL	0.1417 mL	0.2835 mL	0.7087 mL
	100 mM	0.0227 mL	0.1134 mL	0.2268 mL	0.5670 mL