2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. Leriglitazone hydrochloride

Leriglitazone hydrochloride  (Synonyms: MIN-102 hydrochloride; Hydroxypioglitazone hydrochloride)

Cat. No.: HY-117727A Purity: ≥99.0%
COA Handling Instructions

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Leriglitazone (MIN-102; Hydroxypioglitazone) hydrochloride, a metabolite of pioglitazone. Leriglitazone hydrochloride PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy. Leriglitazone hydrochloride binds to the PPARγ C-terminal ligand-binding domain (LBD) with a Ki of 1.2 μM，Leriglitazone induces transcriptional efficacy of the PPARγ (LBD) with an EC50 of 680 nM.

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Leriglitazone hydrochloride Chemical Structure

Leriglitazone hydrochloride Chemical Structure

CAS No. : 146062-46-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Leriglitazone hydrochloride:

Leriglitazone hydrochloride Related Antibodies

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Description

Leriglitazone (MIN-102; Hydroxypioglitazone) hydrochloride, a metabolite of pioglitazone. Leriglitazone hydrochloride PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy. Leriglitazone hydrochloride binds to the PPARγ C-terminal ligand-binding domain (LBD) with a Ki of 1.2 μM，Leriglitazone induces transcriptional efficacy of the PPARγ (LBD) with an EC50 of 680 nM[1].

IC50 & Target[1]

PPAR-γ

 

Clinical Trial
Molecular Weight

408.90

Formula

C19H21ClN2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1)SC(CC2=CC=C(OCCC3=NC=C(C(O)C)C=C3)C=C2)C1=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (122.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4456 mL 12.2279 mL 24.4559 mL
5 mM 0.4891 mL 2.4456 mL 4.8912 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.58%

COA (246 KB) LCMS (256 KB) Elemental Analysis Report (104 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4456 mL 12.2279 mL 24.4559 mL 61.1396 mL
5 mM 0.4891 mL 2.4456 mL 4.8912 mL 12.2279 mL
10 mM 0.2446 mL 1.2228 mL 2.4456 mL 6.1140 mL
15 mM 0.1630 mL 0.8152 mL 1.6304 mL 4.0760 mL
20 mM 0.1223 mL 0.6114 mL 1.2228 mL 3.0570 mL
25 mM 0.0978 mL 0.4891 mL 0.9782 mL 2.4456 mL
30 mM 0.0815 mL 0.4076 mL 0.8152 mL 2.0380 mL
40 mM 0.0611 mL 0.3057 mL 0.6114 mL 1.5285 mL
50 mM 0.0489 mL 0.2446 mL 0.4891 mL 1.2228 mL
60 mM 0.0408 mL 0.2038 mL 0.4076 mL 1.0190 mL
80 mM 0.0306 mL 0.1528 mL 0.3057 mL 0.7642 mL
100 mM 0.0245 mL 0.1223 mL 0.2446 mL 0.6114 mL
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Leriglitazone hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Leriglitazone146062-46-6MIN-102HydroxypioglitazoneMIN102MIN 102PPARPeroxisome proliferator-activated receptorsMetabolitePPARγ LBDInhibitorinhibitorinhibit

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