Cytochalasin E 

Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation^[1][2].

Cytochalasin E prominently inhibits the growth of A549 cells in a dose-dependent manner^[3].
Cytochalasin E could induce the up-regulation of autophagy-related protein (LC3-II) and SQSTM1/p62^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

495.56

C₂₈H₃₃NO₇

36011-19-5

Solid

White to off-white

O=C1[C@]2(O3)[C@]([C@@H]([C@](O4)(C)[C@@H]4[C@]2([H])/C=C/C[C@@H](C([C@](C)(O)/C=C/OC3=O)=O)C)C)([H])[C@H](CC5=CC=CC=C5)N1

Room temperature in continental US; may vary elsewhere.

• [1]. Udagawa T, et al. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesisand tumor growth. J Pharmacol Exp Ther. 2000 Aug;294(2):421-7.  [Content Brief]

  [2]. Lu QY, et al. Green tea extract modulates actin remodeling via Rho activity in an in vitro multistep carcinogenicmodel. Clin Cancer Res. 2005 Feb 15;11(4):1675-83.  [Content Brief]

  [3]. Takanezawa Y, et al. Variation in the activity of distinct cytochalasins as autophagy inhibitiors in human lung A549 cells. Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):641-647.  [Content Brief]