D-Glucuronic acid sodium salt monohydrate

Name: D-Glucuronic acid sodium salt monohydrate
Brand: MedChemExpress
SKU: HY-N6612A
Rating: 4.5 (1 reviews)

Cat. No.: HY-N6612A Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

D-Glucuronic acid sodium salt monohydrate is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid sodium salt monohydrate activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid sodium salt monohydrate and its derivative glucurono-lactone can serve as liver detoxifiers, and its derivatives also possess anti-tumor activity.

For research use only. We do not sell to patients.

D-Glucuronic acid sodium salt monohydrate Chemical Structure

CAS No. : 207300-70-7

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of D-Glucuronic acid sodium salt monohydrate:

D-Glucuronic acid sodium monohydrate-¹³C₆ In-stock
D-Glucuronic acid In-stock

1 Publications Citing Use of MCE D-Glucuronic acid sodium salt monohydrate

•Food Chem. 2023 Mar 30;405(Pt A):134807.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Endogenous Metabolite Isoform Specific Products:

View All Isoforms

Human Endogenous Metabolite Microbial Metabolite

View All Toll-like Receptor (TLR) Isoform Specific Products:

View All Isoforms

TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Human Endogenous Metabolite

TLR4

In Vitro

D-Glucuronic acid sodium salt monohydrate (0.05 mM, 22 h) can promote early embryonic development of pig oocytes^[3].
A high concentration of D-Glucuronic acid sodium salt monohydrate (7 mM, 6 h) significantly inhibits the aggregation factor (AF)-mediated aggregation of GEODIA cells^[4]^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay^[3]

Cell Line:	Pig oocytes
Concentration:	0.05 mM
Incubation Time:	22 h
Result:	Had beneficial effects on cumulus expansion, perivitelline space thickness, cytoplasmic maturation, reactive oxygen species level, cortical granule exocytosis, and early embryonic development after parthenogenesis and somatic cell nuclear transfer.

In Vivo

D-Glucuronic acid (0.32 μg, i.t., single dose) sodium salt monohydrate can induce tactile allodynia in Sprague-Dawley rats^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley rats (325-375 g)^[6]
Dosage:	0.32 μg
Administration:	Intrathecal injection (i.t.), single dose
Result:	Caused a significant allodynia 3 hours post injection, which was blocked by coadministered LPS-RS (Lipid A from Rhodobacter sphaeroides, a type of lipopolysaccharide (LPS) that acts as an antagonist to Toll-like receptor 4 (TLR4)).

Molecular Weight

234.14

Formula

C₆H₁₁NaO₈

CAS No.

207300-70-7

Appearance

Solid

Color

White to off-white

SMILES

O=C[C@@H]([C@H]([C@@H]([C@@H](C([O-])=O)O)O)O)O.[H]O[H].[Na+]

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (42.71 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.2709 mL	21.3547 mL	42.7095 mL
5 mM	0.8542 mL	4.2709 mL	8.5419 mL
10 mM	0.4271 mL	2.1355 mL	4.2709 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (279 KB) SDS (394 KB)

COA (253 KB) HNMR (118 KB)

Handling Instructions (2659 KB)

References

[1]. Teng F, et al. Production of d-glucuronic acid from myo-inositol using Escherichia coli whole-cell biocatalyst overexpressing a novel myo-inositol oxygenase from Thermothelomyces thermophile. Enzyme Microb Technol. 2019 Aug;127:70-74. [Content Brief]

[2]. el-Nezhawy AO, et al. Design, synthesis and antitumor activity of novel D-Glucuronic acid sodium salt monohydrate derivatives. Med Chem. 2011 Nov;7(6):624-38. [Content Brief]

[3]. Lee J, et al. Effect of D-Glucuronic acid sodium salt monohydrate and N-acetyl-D-Glucosamine Treatment during In Vitro Maturation on Embryonic Development after Parthenogenesis and Somatic Cell Nuclear Transfer in Pigs. Animals (Basel). 2021 Apr 6;11(4):1034. [Content Brief]

[4]. Müller WE, et al. Purification and characterization of a species-specific aggregation factor in sponges. Exp Cell Res. 1973 Jul;80(1):95-104. [Content Brief]

[5]. Vaith P, et al. On the role of D-Glucuronic acid sodium salt monohydrate in the aggregation of cells from the marine sponge Geodia cydonium. Dev Comp Immunol. 1979 Spring;3(2):259-75. [Content Brief]

[6]. Lewis SS, et al. Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain. Brain Behav Immun. 2013 May;30:24-32. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.2709 mL	21.3547 mL	42.7095 mL	106.7737 mL
	5 mM	0.8542 mL	4.2709 mL	8.5419 mL	21.3547 mL
	10 mM	0.4271 mL	2.1355 mL	4.2709 mL	10.6774 mL
	15 mM	0.2847 mL	1.4236 mL	2.8473 mL	7.1182 mL
	20 mM	0.2135 mL	1.0677 mL	2.1355 mL	5.3387 mL
	25 mM	0.1708 mL	0.8542 mL	1.7084 mL	4.2709 mL
	30 mM	0.1424 mL	0.7118 mL	1.4236 mL	3.5591 mL
	40 mM	0.1068 mL	0.5339 mL	1.0677 mL	2.6693 mL