1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. 19(S)-HETE

19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC50 value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels.

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19(S)-HETE Chemical Structure

19(S)-HETE Chemical Structure

CAS No. : 115461-40-0

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Based on 1 publication(s) in Google Scholar

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Description

19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC50 value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels[1].

In Vitro

19(S)-HETE (1 μM; 15 min) dose-dependently induces cAMP in MEG-01 cells with an EC50 value of 520 nM[1].
19(S)-HETE (1 μM-1 M) dose-dependently activates the IP receptor with an EC50 value of 567 nM[1].
19(S)-HETE (10 μM-1 M) displaces 3H-iloprost of IP receptor expressed COS-1 cells with a Ki value of 660 nM[1].
19(S)-HETE (3 μM) relaxes arterial blood vessels and inhibits platelet activation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

320.47

Formula

C20H32O3

CAS No.
SMILES

C[C@H](O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O

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19(S)-HETE Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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19(S)-HETE
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HY-142972
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