19(S)-HETE
19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC50 value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels.
For research use only. We do not sell to patients.
- CAS No.: 115461-40-0
- Formula: C20H32O3
- Molecular Weight:320.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
19(S)-HETE (1 μM; 15 min) dose-dependently induces cAMP in MEG-01 cells with an EC50 value of 520 nM[1]. 19(S)-HETE (1 μM-1 M) dose-dependently activates the IP receptor with an EC50 value of 567 nM[1]. 19(S)-HETE (10 μM-1 M) displaces 3H-iloprost of IP receptor expressed COS-1 cells with a Ki value of 660 nM[1]. 19(S)-HETE (3 μM) relaxes arterial blood vessels and inhibits platelet activation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 115461-40-0
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Molecular Weight 320.47
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Formula C20H32O3
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SMILES
C[C@H](O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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