3-Hydroxybutyric acid-d4 sodium
Based on 1 Customer Validation
3-Hydroxybutyric acid-d4 (sodium) is the deuterium labeled 3-Hydroxybutyric acid. 3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids.
For research use only. We do not sell to patients.
- Purity: 99.74%
- CAS No.: 1219804-68-8
- Formula: C4H3D4NaO3
- Molecular Weight:130.11
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
More
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>15 mM
Compound: 10
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Cytotoxicity against HEK293 cells harboring pendrin P123S mutant after 72 hrs by MTT assay
Cytotoxicity against HEK293 cells harboring pendrin P123S mutant after 72 hrs by MTT assay
|
[PMID: 28341401] |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1219804-68-8
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Unlabeled Cas 150-83-4
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Appearance Solid
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Molecular Weight 130.11
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Formula C4H3D4NaO3
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Color White to off-white
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SMILES
[2H]C([2H])([2H])C([2H])(O)CC(O[Na])=O
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Synonyms
β-Hydroxybutyric acid-d4 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : ≥ 100 mg/mL (768.58 mM)
Ethanol : ≥ 5 mg/mL (38.43 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Hsu TT, et al. 3-Hydroxybutyric acid interacts with lipid monolayers at concentrations that impair consciousness. Langmuir. 2013 Feb 12;29(6):1948-55. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / H2O | 1 mM | 7.6858 mL | 38.4290 mL | 76.8580 mL | 192.1451 mL |
| 5 mM | 1.5372 mL | 7.6858 mL | 15.3716 mL | 38.4290 mL | |
| 10 mM | 0.7686 mL | 3.8429 mL | 7.6858 mL | 19.2145 mL | |
| 15 mM | 0.5124 mL | 2.5619 mL | 5.1239 mL | 12.8097 mL | |
| 20 mM | 0.3843 mL | 1.9215 mL | 3.8429 mL | 9.6073 mL | |
| 25 mM | 0.3074 mL | 1.5372 mL | 3.0743 mL | 7.6858 mL | |
| 30 mM | 0.2562 mL | 1.2810 mL | 2.5619 mL | 6.4048 mL | |
| H2O | 40 mM | 0.1921 mL | 0.9607 mL | 1.9215 mL | 4.8036 mL |
| 50 mM | 0.1537 mL | 0.7686 mL | 1.5372 mL | 3.8429 mL | |
| 60 mM | 0.1281 mL | 0.6405 mL | 1.2810 mL | 3.2024 mL | |
| 80 mM | 0.0961 mL | 0.4804 mL | 0.9607 mL | 2.4018 mL | |
| 100 mM | 0.0769 mL | 0.3843 mL | 0.7686 mL | 1.9215 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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