1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. 3-Hydroxybutyric acid

3-Hydroxybutyric acid  (Synonyms: β-Hydroxybutyric acid)

Cat. No.: HY-113378 Purity: ≥98.0%
COA Handling Instructions

3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids.

For research use only. We do not sell to patients.

3-Hydroxybutyric acid Chemical Structure

3-Hydroxybutyric acid Chemical Structure

CAS No. : 300-85-6

Size Price Stock Quantity
Solid or liquid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 55 In-stock
Solution
10 mM * 1 mL in Water USD 55 In-stock
Solid or liquid
100 mg USD 50 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of 3-Hydroxybutyric acid:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids[1].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

3-Hydroxybutyric acid (β-Hydroxybutyric acid) is capable of interacting with lipids (modeled using a DPPC monolayer) and altering phase behavior at clinical concentrations. 3-Hydroxybutyric acid also diminishes the interfacial viscosity of DPPC Monolayers[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

104.10

Formula

C4H8O3

CAS No.
Appearance

<33°C Solid,>34°C Liquid

Color

Off-white to light yellow

SMILES

CC(O)CC(O)=O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

0.1 M NaOH : 100 mg/mL (960.61 mM; ultrasonic and adjust pH to 6 with NaOH)

H2O : 50 mg/mL (480.31 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.6061 mL 48.0307 mL 96.0615 mL
5 mM 1.9212 mL 9.6061 mL 19.2123 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (240.15 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / 0.1 M NaOH 1 mM 9.6061 mL 48.0307 mL 96.0615 mL 240.1537 mL
5 mM 1.9212 mL 9.6061 mL 19.2123 mL 48.0307 mL
10 mM 0.9606 mL 4.8031 mL 9.6061 mL 24.0154 mL
15 mM 0.6404 mL 3.2020 mL 6.4041 mL 16.0102 mL
20 mM 0.4803 mL 2.4015 mL 4.8031 mL 12.0077 mL
25 mM 0.3842 mL 1.9212 mL 3.8425 mL 9.6061 mL
30 mM 0.3202 mL 1.6010 mL 3.2020 mL 8.0051 mL
40 mM 0.2402 mL 1.2008 mL 2.4015 mL 6.0038 mL
50 mM 0.1921 mL 0.9606 mL 1.9212 mL 4.8031 mL
60 mM 0.1601 mL 0.8005 mL 1.6010 mL 4.0026 mL
80 mM 0.1201 mL 0.6004 mL 1.2008 mL 3.0019 mL
100 mM 0.0961 mL 0.4803 mL 0.9606 mL 2.4015 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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3-Hydroxybutyric acid Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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3-Hydroxybutyric acid
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