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3-Hydroxybutyric acid

(Synonyms: β-Hydroxybutyric acid)
24 Cited Publications
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Based on 24 publication(s) in Google Scholar

3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids.

For research use only. We do not sell to patients.

  • Purity: 99.31%
  • CAS No.: 300-85-6
  • Formula: C4H8O3
  • Molecular Weight:104.10
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • 3-Hydroxybutyric acid Chemical Structure
    3-Hydroxybutyric acid Chemical Structure
  • Experimental Validation Results for 3-Hydroxybutyric acid
  • Experimental Validation Results for 3-Hydroxybutyric acid
  • Experimental Validation Results for 3-Hydroxybutyric acid
  • Experimental Validation Results for 3-Hydroxybutyric acid
  • Experimental Validation Results for 3-Hydroxybutyric acid
  • Experimental Validation Results for 3-Hydroxybutyric acid
  • Experimental Validation Results for 3-Hydroxybutyric acid
  • Experimental Validation Results for 3-Hydroxybutyric acid
  • Experimental Validation Results for 3-Hydroxybutyric acid
  • Experimental Validation Results for 3-Hydroxybutyric acid
  • Experimental Validation Results for 3-Hydroxybutyric acid
  • Experimental Validation Results for 3-Hydroxybutyric acid
CAS No.: 300-85-6
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  • 3-Hydroxybutyric acid Chemical Structure
    3-Hydroxybutyric acid Chemical Structure
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    3-Hydroxybutyric acid purchased from MedChemExpress. Usage Cited in: Nat Metab. 2025 Jul;7(7):1330-1343. [Abstract]

    Customer Validation
     Osmotic pumps filled with 3-Hydroxybutyric acid (0.5-1 mM, for 7 days) inhibited the proliferation of P. berghei ANKA in female C57BL/6 mice

  • 1/16

    3-Hydroxybutyric acid purchased from MedChemExpress. Usage Cited in: Nat Metab. 2025 Jul;7(7):1330-1343. [Abstract]

    Customer Validation
     The half-maximal inhibitory concentration (IC₅₀) of 3-Hydroxybutyric acid (0-25 mM, 96 h) for inhibiting the in vitro proliferation of the malignant malaria parasite 3D7 strain is 7.268 mM.

  • 1/16

    3-Hydroxybutyric acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 May 7;16(1):4224. [Abstract]

    Customer Validation
     MLTC-1 cells were treated with 3-Hydroxybutyric acid (0, 1, 2, 3, 4, 5 mM) for 24 h before analysis.

  • 1/16

    3-Hydroxybutyric acid purchased from MedChemExpress. Usage Cited in: BMC Neurol. 2025 Apr 10;25(1):153. [Abstract]

    Customer Validation
     PC12 cells were exposed to 100 µM CoCl2, 20 mM 3-Hydroxybutyric acid sodium, and 20 mM 3-Hydroxybutyric acid sodium plus 100 µM CoCl2 for 48 h.

  • 1/16

    3-Hydroxybutyric acid purchased from MedChemExpress. Usage Cited in: BMC Neurol. 2025 Apr 10;25(1):153. [Abstract]

    Customer Validation
     Effect of 3-Hydroxybutyric acid sodium on the proliferation of PC12 cells. EdU staining (red) and Hoechst staining (blue) of PC12 cells treated with 100 µM CoCl2, 20 mM 3-Hydroxybutyric acid sodium, and 20 mM 3-Hydroxybutyric acid sodium (48 h) plus 100 µM CoCl2.

  • 1/16

    3-Hydroxybutyric acid purchased from MedChemExpress. Usage Cited in: BMC Neurol. 2025 Apr 10;25(1):153. [Abstract]

    Customer Validation
     Effect of 3-Hydroxybutyric acid sodium on the expression of P65. PC12 cells were exposed to 100 µM CoCl2, 20 mM 3-Hydroxybutyric acid sodium, and 20 mM 3-Hydroxybutyric acid sodium plus 100 µM CoCl2 for 48 h. The protein level of P65 in the nuclear fraction was analyzed via western blotting.

  • 1/16

    3-Hydroxybutyric acid purchased from MedChemExpress. Usage Cited in: Research Square Preprint. 2024 Aug 08.

    Customer Validation
     Representative western blots for H3K9bhb and H3K9ac and Histone H3. MLTC-1 cells were treated with BHB (3-Hydroxybutyric acid sodium; 1-5 mM) for 24 h before analysis.

  • 1/16

    3-Hydroxybutyric acid purchased from MedChemExpress. Usage Cited in: Research Square Preprint. 2024 Aug 08.

    Customer Validation
     Representative images of H3H9ac staining in MLTC-1 cells treated with BHB (3-Hydroxybutyric acid sodium; 5 mM) for 24 h. Scale bar: 20 μm.

  • 1/16

    3-Hydroxybutyric acid purchased from MedChemExpress. Usage Cited in: Research Square Preprint. 2024 Aug 08.

    Customer Validation
     HDAC activity in MLTC-1 cells treated with BHB (3-Hydroxybutyric acid sodium; 5 mM) or Vorinostat (1 μM). n = 3 per group.

  • 1/16

    3-Hydroxybutyric acid purchased from MedChemExpress. Usage Cited in: Research Square Preprint. 2024 Aug 08.

    Customer Validation
     Representative images of SA-β-gal staining in MLTC-1 cells of the indicated groups. Senescent cells were treated with BHB (3-Hydroxybutyric acid sodium; 5 mM) or Vorinostat (1 μM) for 48 h before staining. Scale bar: 75 μm.

  • 1/16

    3-Hydroxybutyric acid purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Dec 12:S1931-3128(24)00444-X. [Abstract]

    Customer Validation
     3-Hydroxybutyric acid (10 mM, 1.5 h). The dynamic fluorescence intensity of calcium imaging in primary culture of vagal neurons over time in response to butyrate with or without different butyrate receptor antagonists.

  • 1/16

    3-Hydroxybutyric acid purchased from MedChemExpress. Usage Cited in: Cell Metab. 2023 Jan 3;35(1):200-211.e9. [Abstract]

    Customer Validation
     Fluorescence response of FiLa at the indicated concentration of lactate or other metabolites. Data are normalized to the initial value. PEP, phosphoenolpyruvate; α-KG, α-ketoglutarate; BHB, β-hydroxybutyrate

  • 3-Hydroxybutyric acid