3,4-Dihydroxybenzeneacetic acid-d5
Based on 1 Customer Validation
3,4-Dihydroxybenzeneacetic acid-d5 is the deuterium labeled 3,4-Dihydroxybenzeneacetic acid. 3,4-Dihydroxybenzeneacetic acid is the main neuronal metabolite of dopamine.
For research use only. We do not sell to patients.
- Purity: 98.67%
- CAS No.: 60696-39-1
- Formula: C8H3D5O4
- Molecular Weight:173.18
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 60696-39-1
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Unlabeled Cas 102-32-9
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Appearance Solid
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Molecular Weight 173.18
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Formula C8H3D5O4
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Color Off-white to gray
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SMILES
OC(C([2H])([2H])C1=C([2H])C(O)=C(C([2H])=C1[2H])O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (577.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (288.72 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Goldstein DS, et al. Elevated cerebrospinal fluid ratios of cysteinyl-dopamine/3,4-dihydroxyphenylacetic acid in parkinsonian synucleinopathies. Parkinsonism Relat Disord. 2016 Oct;31:79-86. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 5.7743 mL | 28.8717 mL | 57.7434 mL | 144.3585 mL |
| 5 mM | 1.1549 mL | 5.7743 mL | 11.5487 mL | 28.8717 mL | |
| 10 mM | 0.5774 mL | 2.8872 mL | 5.7743 mL | 14.4358 mL | |
| 15 mM | 0.3850 mL | 1.9248 mL | 3.8496 mL | 9.6239 mL | |
| 20 mM | 0.2887 mL | 1.4436 mL | 2.8872 mL | 7.2179 mL | |
| 25 mM | 0.2310 mL | 1.1549 mL | 2.3097 mL | 5.7743 mL | |
| 30 mM | 0.1925 mL | 0.9624 mL | 1.9248 mL | 4.8119 mL | |
| 40 mM | 0.1444 mL | 0.7218 mL | 1.4436 mL | 3.6090 mL | |
| 50 mM | 0.1155 mL | 0.5774 mL | 1.1549 mL | 2.8872 mL | |
| 60 mM | 0.0962 mL | 0.4812 mL | 0.9624 mL | 2.4060 mL | |
| 80 mM | 0.0722 mL | 0.3609 mL | 0.7218 mL | 1.8045 mL | |
| 100 mM | 0.0577 mL | 0.2887 mL | 0.5774 mL | 1.4436 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
3,4-Dihydroxybenzeneacetic acid-d5 Related Classifications
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