Art. -Nr.: HY-N8210

Homoeriodictyol

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Homoeriodictyol is an orally active, bitter-tasting flavanone that can penetrate the blood-brain barrier. Homoeriodictyol enhances synaptic-related protein expression through NCOA4-mediated ferritin autophagy. Homoeriodictyol improves memory impairment in mice by inhibiting the NLRP3 inflammasome. Homoeriodictyol protects human endothelial cells from oxidative damage by activating Nrf2 and inhibiting mitochondrial dysfunction. Homoeriodictyol enhances ROS activity and induces apoptosis, exhibiting anticancer effects. Homoeriodictyol inhibits the survival and migration of androgen-resistant prostate cancer cells in vitro. Homoeriodictyol exerts antinociceptive activity in mice in vivo.

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Reinheit: 99.86%
CAS. Nr.: 446-71-9
Formel: C₁₆H₁₄O₆
Molecular Weight:302.28

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Homoeriodictyol Chemical Structure

CAS. Nr.: 446-71-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[4]

Caspase 3

Caspase-9

Alle MMP Isoform-spezifische Produkte anzeigen :

Alle Caspase Isoform-spezifische Produkte anzeigen :

Alle PARP Isoform-spezifische Produkte anzeigen :

In Vitro

Homoeriodictyol (0.1-1 μM) increases cell viability, PSD-95, SYN, P62, and FTH levels, and decreases LC3 and NCOA4 levels in Corticosterone (HY-B1618)-induced SH-SY5Y cells^[1].
Homoeriodictyol (10 μM/L, 24 h) restores cell viability and migration levels, and reduces inflammatory factor levels in N9 microglial cells^[2].
Homoeriodictyol (0-20 μM, 16 h) upregulates the protein levels of Nrf2 and γGCS in MDA-MB-231 cells^[3].
Homoeriodictyol (1-5 μM, 12-24 h) prevents mitochondrial dysfunction and apoptosis, reduces MMP, cytochrome C, tAIF, cleaved caspase -3, -9 and PARP levels in H₂O₂-induced EA.hy926 cells ^[3].
Homoeriodictyol (0-5 μM, 2-24 h) activats the Nrf2 pathway through inducing Nrf2 at the protein level and enhancing Nrf2 stability in EA.hy926 cells^[3].
Homoeriodictyol (100-500 μg/mL, 24 h) shows cytotoxicity and concentration-dependent lysosomal toxicity, enhances intracellular ROS generation and induces mitochondrial dysfunction in MCF-7, HeLa, and HT-29 cells^[4].
Homoeriodictyol (500 μg/mL, 24 h) increases the subG1 peaks, increases the expressions of p53, caspase 3, caspase 9, bax, and SOD1 genes in MCF-7, HeLa, and HT-29 cells^[4].
Homoeriodictyol (0-250 μM, 24-72 h) reduced cell viability against PC3 cells, with an IC₅₀ of 118.15 μM, induces apoptosis, inhibits cell migration in PC3 cells^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[2]

Cell Line:

N9 microglial cells
Concentration:

10 μM/L
Incubation Time:

24 h
Result:

Reduced levels of IL-1β and IL-18.

Cell Migration Assay ^[2]

Cell Line:

N9 microglial cells
Concentration:

10 μM/L
Incubation Time:

24 h
Result:

Restored migration levels.

Western Blot Analysis^[3]

Cell Line:

MDA-MB-231 cells
Concentration:

0, 2.5, 5 ,10, 20 μM
Incubation Time:

16 h
Result:

Upregulated the protein levels of Nrf2 and γGCS.

Apoptosis Analysis^[3]

Cell Line:

H₂O₂-induced EA.hy926 cells
Concentration:

2, 5 μM
Incubation Time:

24 h
Result:

Decreased apoptosis cells.

Immunofluorescence^[3]

Cell Line:

EA.hy926 cells
Concentration:

2, 5 μM
Incubation Time:

12 h
Result:

Activated the nuclear translocation of Nrf2 protein.

Western Blot Analysis^[3]

Cell Line:

EA.hy926 cells
Concentration:

1, 2, 5 μM
Incubation Time:

2, 4, 6, 8, 12, 16 h
Result:

Activated the nuclear translocation of Nrf2 protein.
Increased protein levels of Nrf2, NQO1, and γGCS, continued to increase Nrf2 protein levels over the 24 hours tested.

RT-PCR^[3]

Cell Line:

EA.hy926 cells
Concentration:

1, 2, 5 μM
Incubation Time:

24 h
Result:

Did not affect mRNA level of Nrf2, but upregulated the levels of NQO1 and GCLM.

Immunofluorescence^[3]

Cell Line:

H₂O₂-induced EA.hy926 cells
Concentration:

2, 5 μM
Incubation Time:

12 h
Result:

Reduce MMP levels.
Reduced cytochrome C protein levels in the cytoplasm and mitochondria.
Inhibited tAIF production and blocks AIF translocation from mitochondria to the nucleus.

Western Blot Analysis^[3]

Cell Line:

H₂O₂-induced EA.hy926 cells
Concentration:

1, 2, 5 μM
Incubation Time:

12 h
Result:

Reduced cytochrome C protein levels in the cytoplasm and mitochondria.
Inhibited tAIF production and blocks AIF translocation from mitochondria to the nucleus.
Inhibited H₂O₂-induced activations of cleaved caspases -3, -9 and PARP.

Immunofluorescence^[4]

Cell Line:

MCF-7, HeLa, and HT-29 cells
Concentration:

500 μg/mL
Incubation Time:

24 h
Result:

Increased the green fluorescence of DCF, increased the fluorescence of Rh123 fluorescence.

Cell Cycle Analysis^[4]

Cell Line:

MCF-7, HeLa, and HT-29 cells
Concentration:

500 μg/mL
Incubation Time:

24 h
Result:

Increased the subG1 peaks.

RT-PCR^[4]

Cell Line:

MCF-7, HeLa, and HT-29 cells
Concentration:

100 μg/mL
Incubation Time:

24 h
Result:

Increased the expressions of p53, caspase 3, caspase 9, bax, and SOD1 genes.

Apoptosis Analysis^[6]

Cell Line:

PC3 cells
Concentration:

PC3 cells
Incubation Time:

72 h
Result:

Induced apoptosis, reduced cell density and disrupted cell morphology, enhanced the efficacy of Docetaxel (HY-B0011) leading to higher apoptosis rates.
Increased the mRNA expression of BAX, CASP3, CASP8, and CYCS, upregulated TP53, along with enhanced expression of caspases in combination with Docetaxel.

Cell Migration Assay ^[6]

Cell Line:

PC3 cells
Concentration:

100 μM
Incubation Time:

24 h
Result:

Reduced migration, reduced TWIST, SNAIL, and ZEB1 mRNA expression levels by 59%, 68%, and 42%, respectively, compared to untreated cells.

In Vivo

Homoeriodictyol (10 mg/kg/d, p.o., 4 weeks) improves Aβ25-35-induced memory impairment by inhibiting the NLRP3 inflammasome to reduce inflammation in AD kunming mice model^[2].
Homoeriodictyol (50-μg/kg, i.p., once) exhibits antinociceptive activity through both central and peripheral pathways in swiss albino mice model^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Aβ25-35-induced AD kunming mice (Male, 7 weeks old) model^[1]
Dosage:

10 mg/kg/d
Administration:

p.o., 4 weeks
Result:

Improved memory impairment and cognitive dysfunction, alleviated hippocampal neuronal damage.
Decreased the levels of Aβ_1-40, Aβ_1-42, and p-Tau in the hippocampus.
Reduced oxidative stress in the brain, reduced the levels of ROS, apoptosis and MDA, increased the levels of GSH-Px and SOD.
Resulted in increased numbers of NK cells, Th cells, Tc cells, and DCs, and decreased numbers of MDSCs and Treg cells in peripheral blood and splenic tissues.
Had excellent anti-inflammatory effects, reduced the protein expression levels of NLRP3, Caspase-1, and ASC, and the inflammatory factors IL-18 and IL-1β in brain tissue.

Animal Model:

Swiss albino mice (adult male, 24-28 g) model^[5]
Dosage:

50, 100, 150, and 200 μg/kg
Administration:

i.p., once
Result:

Lowered the writhing responses to acetic acid, showed a dose-responsive relation analgesic effect.
Increased the time respond to thermal pain on a hot plate.
Decreased the licking times in both the early and late phases after formalin injection, alleviated pain in the formalin test.
Lessened licking time after Capsaicin (HY-10448) injection, indicating a dose-responsive effect.
Reduced paw licking times, mitigated glutamate-induced pain responses.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 446-71-9
Appearance Solid
Molecular Weight 302.28
Formel C₁₆H₁₄O₆
Color White to off-white
SMILES

O=C1C[C@@H](C2=CC=C(O)C(OC)=C2)OC3=CC(O)=CC(O)=C13
Structure Classification
- Flavonoids
- Flavonones
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (165.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3082 mL

16.5410 mL

33.0819 mL

5 mM

0.6616 mL

3.3082 mL

6.6164 mL

10 mM

0.3308 mL

1.6541 mL

3.3082 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 1.25 mg/mL (4.14 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 1.25 mg/mL (4.14 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.25 mg/mL (4.14 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (292 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang M, et al. Hesperidin alleviated dendritic spines through inhibiting ferritinophagy via HERC2-NCOA4 ubiquitination in CUMS mice. Phytomedicine. 2024 Dec;135:156132. [Content Brief]

[2]. Guo P, et al. Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ25-35-Induced Mice by Inhibiting the NLRP3 Inflammasome. Molecules. 2022 Apr 12;27(8):2488. [Content Brief]

[3]. Shen T, et al. Homoeriodictyol protects human endothelial cells against oxidative insults through activation of Nrf2 and inhibition of mitochondrial dysfunction. Vascul Pharmacol. 2018 Oct;109:72-82. [Content Brief]

[4]. Quaiser Saquib, et al. Anticancer efficacies of persicogenin and homoeriodictyol isolated from Rhus retinorrhoea. Process Biochemistry, ISSN: 1359-5113, Vol: 95, Page: 186-196.

[5]. Al-Bzour M H, et al. Exploring the antinociceptive potential of homoeriodictyol in nociception models[J]. J. Pharm. Pharmacogn. Res, 2024, 12: 615-623.

[6]. Güvenç A, et al. HOMOERIODICTYOL INHIBITS SURVIVAL AND MIGRATION OF ANDROGEN-RESISTANT PROSTATE CANCER CELLS IN VITRO. Exp Oncol. 2025 Jul 11;47(1):34-43. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.3082 mL	16.5410 mL	33.0819 mL	82.7048 mL
	5 mM	0.6616 mL	3.3082 mL	6.6164 mL	16.5410 mL
	10 mM	0.3308 mL	1.6541 mL	3.3082 mL	8.2705 mL
	15 mM	0.2205 mL	1.1027 mL	2.2055 mL	5.5137 mL
	20 mM	0.1654 mL	0.8270 mL	1.6541 mL	4.1352 mL
	25 mM	0.1323 mL	0.6616 mL	1.3233 mL	3.3082 mL
	30 mM	0.1103 mL	0.5514 mL	1.1027 mL	2.7568 mL
	40 mM	0.0827 mL	0.4135 mL	0.8270 mL	2.0676 mL
	50 mM	0.0662 mL	0.3308 mL	0.6616 mL	1.6541 mL
	60 mM	0.0551 mL	0.2757 mL	0.5514 mL	1.3784 mL
	80 mM	0.0414 mL	0.2068 mL	0.4135 mL	1.0338 mL
	100 mM	0.0331 mL	0.1654 mL	0.3308 mL	0.8270 mL

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Homoeriodictyol

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

CNS-Penetrant Compound Library

Autophagy Compound Library

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Phenols Library

Pyroptosis Compound Library

Orally Active Compound Library

Glutamine Metabolism Compound Library

Traditional Chinese Medicine Active Compound Library

Flavonoids Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

Food-Sourced Compound Library

Drug Metabolite Library

Anti-Cancer Natural Product Library

Antidepressant Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Pain-Related Compound Library

Protease Inhibitor Library

Cell Death Library

Anti-Drug-Resistant Compound Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

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Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Anti-Fibrosis Compound Library

Miao Ethnicity Medicine Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

RO5 Drug-like Natural Product Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Metabolite Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Alle MMP Isoform-spezifische Produkte anzeigen

Alle Caspase Isoform-spezifische Produkte anzeigen

Alle PARP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Homoeriodictyol Related Classifications

HY-N8210 Related Classifications