1,3,7-Trimethyluric acid
Based on 1 Customer Validation
1,3,7-Trimethyluric acid is the metabolite of caffeine. The metabolic ratio 1,3,7-Trimethyluric acid to caffeine can be evaluated as a biomarker to describe variability in CYP3A activity in a cohort.
For research use only. We do not sell to patients.
- Purity: 99.99%
- CAS No.: 5415-44-1
- Formula: C8H10N4O3
- Molecular Weight:210.19
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Chemical Information
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CAS No. 5415-44-1
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Appearance Solid
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Molecular Weight 210.19
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Formula C8H10N4O3
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Color White to off-white
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SMILES
O=C(N1C)N(C)C2=C(N(C)C(N2)=O)C1=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (118.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Y Benchekroun, et al. Isotopic effects on retention times of caffeine and its metabolites 1,3,7-trimethyluric acid, theophylline, theobromine and paraxanthine. J Chromatogr B Biomed Sci Appl. 1997 Jan 24;688(2):245-54. [Content Brief]
[2]. Madelé van Dyk, et al. Identification of the caffeine to trimethyluric acid ratio as a dietary biomarker to characterise variability in cytochrome P450 3A activity. Eur J Clin Pharmacol. 2019 Sep;75(9):1211-1218. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7576 mL | 23.7880 mL | 47.5760 mL | 118.9400 mL |
| 5 mM | 0.9515 mL | 4.7576 mL | 9.5152 mL | 23.7880 mL | |
| 10 mM | 0.4758 mL | 2.3788 mL | 4.7576 mL | 11.8940 mL | |
| 15 mM | 0.3172 mL | 1.5859 mL | 3.1717 mL | 7.9293 mL | |
| 20 mM | 0.2379 mL | 1.1894 mL | 2.3788 mL | 5.9470 mL | |
| 25 mM | 0.1903 mL | 0.9515 mL | 1.9030 mL | 4.7576 mL | |
| 30 mM | 0.1586 mL | 0.7929 mL | 1.5859 mL | 3.9647 mL | |
| 40 mM | 0.1189 mL | 0.5947 mL | 1.1894 mL | 2.9735 mL | |
| 50 mM | 0.0952 mL | 0.4758 mL | 0.9515 mL | 2.3788 mL | |
| 60 mM | 0.0793 mL | 0.3965 mL | 0.7929 mL | 1.9823 mL | |
| 80 mM | 0.0595 mL | 0.2974 mL | 0.5947 mL | 1.4868 mL | |
| 100 mM | 0.0476 mL | 0.2379 mL | 0.4758 mL | 1.1894 mL |
1,3,7-Trimethyluric acid Related Classifications
HY-113327 Related Classifications
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