2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Ezetimibe phenoxy glucuronide

Ezetimibe phenoxy glucuronide  (Synonyms: Ezetimibe glucuronide; Ezetimibe β-D-glucuronide)

Cat. No.: HY-135391 Purity: 99.63%
COA Handling Instructions

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Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity. Ezetimibe is a potent cholesterol absorption inhibitor.

For research use only. We do not sell to patients.

Ezetimibe phenoxy glucuronide Chemical Structure

Ezetimibe phenoxy glucuronide Chemical Structure

CAS No. : 190448-57-8

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1 mg USD 260 In-stock
5 mg USD 800 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Ezetimibe phenoxy glucuronide:

Ezetimibe phenoxy glucuronide Related Antibodies

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Description

Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].

In Vivo

After oral administration, Ezetimibe is absorbed in the small intestine and more than 80% of Ezetimibe metabolized to Ezetimibe Glucuronide[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

585.55

Formula

C30H29F2NO9
CAS No.
Appearance

Solid

Color

White to pink

SMILES

O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC=C([C@H]([C@H]3CC[C@@H](C4=CC=C(F)C=C4)O)N(C5=CC=C(F)C=C5)C3=O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (170.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7078 mL 8.5390 mL 17.0780 mL
5 mM 0.3416 mL 1.7078 mL 3.4156 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.63%

COA (250 KB) HNMR (134 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7078 mL 8.5390 mL 17.0780 mL 42.6949 mL
5 mM 0.3416 mL 1.7078 mL 3.4156 mL 8.5390 mL
10 mM 0.1708 mL 0.8539 mL 1.7078 mL 4.2695 mL
15 mM 0.1139 mL 0.5693 mL 1.1385 mL 2.8463 mL
20 mM 0.0854 mL 0.4269 mL 0.8539 mL 2.1347 mL
25 mM 0.0683 mL 0.3416 mL 0.6831 mL 1.7078 mL
30 mM 0.0569 mL 0.2846 mL 0.5693 mL 1.4232 mL
40 mM 0.0427 mL 0.2135 mL 0.4269 mL 1.0674 mL
50 mM 0.0342 mL 0.1708 mL 0.3416 mL 0.8539 mL
60 mM 0.0285 mL 0.1423 mL 0.2846 mL 0.7116 mL
80 mM 0.0213 mL 0.1067 mL 0.2135 mL 0.5337 mL
100 mM 0.0171 mL 0.0854 mL 0.1708 mL 0.4269 mL
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Ezetimibe phenoxy glucuronide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ezetimibe phenoxy glucuronide190448-57-8Ezetimibe glucuronide Ezetimibe β-D-glucuronideDrug MetaboliteInhibitorinhibitorinhibit

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