Severe hepatic side effects of ezetimibe

  • Clin Gastroenterol Hepatol. 2006 Jul;4(7):908-11. doi: 10.1016/j.cgh.2006.04.014.
Mark F J Stolk  1 ,  Marco C J M Becx ,  Karel C Kuypers ,  Cees A Seldenrijk
Affiliations
  • 1. Department of Gastroenterology, St. Antonius Hospital, Nieuwegein, The Netherlands. [email protected]
PMID: 16797241 DOI: 10.1016/j.cgh.2006.04.014
Abstract

Background and aims: Ezetimibe was introduced recently as a new class of cholesterol-lowering drugs. Until now only limited increases of transaminase levels were reported.

Methods: We studied 2 patients with severe hepatic side effects of ezetimibe in a general community hospital.

Results: Ezetimibe may lead to 2 distinct types of severe hepatic side effects.

Conclusions: Ezetimibe may rarely cause hepatotoxicity, severe cholestatic hepatitis, or acute autoimmune hepatitis.

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