2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. Quinaprilat

Quinaprilat is an orally active non-mercapto Angiotensin Converting Enzyme (ACE) inhibitor, the active metabolite of Quinapril. Quinaprilat specifically blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II and inhibits the degradation of bradykinin. Quinaprilat acts as anti-hypertensive agent and vasodilator.

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Quinaprilat Chemical Structure

Quinaprilat Chemical Structure

CAS No. : 82768-85-2

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Quinaprilat Related Antibodies

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Description

Quinaprilat is an orally active non-mercapto Angiotensin Converting Enzyme (ACE) inhibitor, the active metabolite of Quinapril. Quinaprilat specifically blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II and inhibits the degradation of bradykinin. Quinaprilat acts as anti-hypertensive agent and vasodilator[1][2].

In Vitro

Quinaprilat (5 μM) mediates the interaction of organic anion transporter 3 (hOAT3) which can promote renal active secretion of quinapril that increases uptake of quinaprilat to 25-fold in HEK293 cells and hOAT3 affinity Km for quinaprilat is 13.4 μM[1].
Quinaprilat (100 nM, 20 min) can inhibit the activity of protein kinase C (PKC) by activing the B1 receptor resulting in the release of NO in human lung microvascular endothelial (HLMVE) cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Quinaprilat Related Antibodies
In Vivo

Quinaprilat (oral gavage, 3 mg/kg, every day, 6 days) has some anti-hypertensive effect by combining with other drugs in male spontaneous hypertensive rats (SHRs)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male spontaneous hypertensive rats (SHRs) (230-250 g)[1]
Dosage: 3 mg/kg
Administration: Oral gavage; every day; 6 days
Result: Caused a significant drop in blood pressure from day 1 to day 5 by combining quinapril and gemcabene while each alone had no effect. Decreased plasma concentration of quinaprilat on the fifth day.
Animal Model:
Dosage:
Administration:
Result: Result: The pharmacokinetic parameters of quinaprilat
Parameter
AUC(0-24 h) 4.62 μM/h
Ae(0-24 h) 23.1 μg
renal clearance 31.0 mL/h
Molecular Weight

410.46

Formula

C23H26N2O5
CAS No.
SMILES

O=C(O)[C@H]1N(CC2=C(C1)C=CC=C2)C([C@H](C)N[C@@H](CCC3=CC=CC=C3)C(O)=O)=O
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Quinaprilat Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinaprilat82768-85-2Angiotensin-converting Enzyme (ACE)ACE inhibitoranti-hypertensivevasodilatorangiotensinInhibitorinhibitorinhibit

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