Quinaprilat hydrate
Quinaprilat hydrate is a non-mercapto Angiotensin Converting Enzyme (ACE) inhibitor, the active metabolite of Quinapril. Quinaprilat hydrate specifically blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II and inhibits the degradation of bradykinin. Quinaprilat hydrate acts as anti-hypertensive agent and vasodilator.
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- CAS No.: 1435786-09-6
- Formule: C23H28N2O6
- Masse moléculaire:428.48
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Activité biologique
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Activité biologique
Quinaprilat (5 μM) hydrate mediates the interaction of organic anion transporter 3 (hOAT3) which can promote renal active secretion of Quinaprilat hydrate that increases uptake of Quinaprilat hydrate to 25-fold in HEK293 cells and hOAT3 affinity Km for Quinaprilat hydrate is 13.4 μM[1].
Quinaprilat (100 nM, 20 min) hydrate can inhibit the activity of protein kinase C (PKC) by activing the B1 receptor resulting in the release of NO in human lung microvascular endothelial (HLMVE) cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Parameter | |
| AUC(0-24 h) | 4.62 μM/h |
| Ae(0-24 h) | 23.1 μg |
| renal clearance | 31.0 mL/h |
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