Quinaprilat hydrochloride
Quinaprilat hydrochloride is an orally active non-mercapto Angiotensin Converting Enzyme (ACE) inhibitor, the active metabolite of Quinapril. Quinaprilat hydrochloride specifically blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II and inhibits the degradation of bradykinin. Quinaprilat hydrochloride acts as anti-hypertensive agent and vasodilator.
For research use only. We do not sell to patients.
- CAS No.: 82586-58-1
- Formula: C23H27ClN2O5
- Molecular Weight:446.92
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Quinaprilat (5 μM) hydrochloride mediates the interaction of organic anion transporter 3 (hOAT3) which can promote renal active secretion of Quinaprilat hydrochloride that increases uptake of Quinaprilat hydrochloride to 25-fold in HEK293 cells and hOAT3 affinity Km for Quinaprilat hydrate is 13.4 μM[1].
Quinaprilat (100 nM, 20 min) hydrochloride can inhibit the activity of protein kinase C (PKC) by activing the B1 receptor resulting in the release of NO in human lung microvascular endothelial (HLMVE) cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male spontaneous hypertensive rats (SHRs) (230-250 g)[1]
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Dosage:3 mg/kg
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Administration:Oral gavage; every day; 6 days
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Result:Caused a significant drop in blood pressure from day 1 to day 5 by combining quinapril and gemcabene while each alone had no effect. Decreased plasma concentration of quinaprilat on the fifth day.
Chemical Information
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CAS No. 82586-58-1
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Molecular Weight 446.92
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Formula C23H27ClN2O5
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SMILES
OC([C@H](CCC1=CC=CC=C1)N[C@@H](C)C(N2[C@@H](CC3=CC=CC=C3C2)C(O)=O)=O)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Haodan Yuan, et al. Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril. J Pharmacol Exp Ther. 2009 Jul;330(1):191-7. doi: 10.1124/jpet.108.149476. Epub 2009 Apr 6. [Content Brief]
[2]. Sinisa Stanisavljevic, et al. Angiotensin I-converting enzyme inhibitors block protein kinase C epsilon by activating bradykinin B1 receptors in human endothelial cells. J Pharmacol Exp Ther. 2006 Mar;316(3):1153-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Quinaprilat hydrochloride Related Classifications
HY-127026B Related Classifications
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