2-Methylcitric acid trisodium
Based on 1 Customer Validation
2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate.
For research use only. We do not sell to patients.
- Purity: 96.0%
- CAS No.: 117041-96-0
- Formula: C7H7Na3O7
- Molecular Weight:272.10
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Biological Activity
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Human Endogenous Metabolite |
2-Methylcitric acid trisodium impairs glutamate metabolism and induces permeability transition in brain mitochondria[1].
2-Methylcitric acid trisodium inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM[1].
2-Methylcitric acid trisodium (1 mM, 3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca2+-loaded mitochondria supported by different substrates[1].
2-Methylcitric acid trisodium behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis[1].
2-Methylcitric acid trisodium does not significantly impair mitochondrial glutamate transport[1].
2-Methylcitric acid trisodium does not significantly impair glutamate mitochondrial transport in liver mitochondria[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 117041-96-0
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Appearance Solid
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Molecular Weight 272.10
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Formula C7H7Na3O7
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Color White to off-white
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SMILES
CC(C(O[Na])=O)C(C(O[Na])=O)(O)CC(O[Na])=O
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Synonyms
Methylcitric acid trisodium
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (367.51 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.6751 mL | 18.3756 mL | 36.7512 mL | 91.8780 mL |
| 5 mM | 0.7350 mL | 3.6751 mL | 7.3502 mL | 18.3756 mL | |
| 10 mM | 0.3675 mL | 1.8376 mL | 3.6751 mL | 9.1878 mL | |
| 15 mM | 0.2450 mL | 1.2250 mL | 2.4501 mL | 6.1252 mL | |
| 20 mM | 0.1838 mL | 0.9188 mL | 1.8376 mL | 4.5939 mL | |
| 25 mM | 0.1470 mL | 0.7350 mL | 1.4700 mL | 3.6751 mL | |
| 30 mM | 0.1225 mL | 0.6125 mL | 1.2250 mL | 3.0626 mL | |
| 40 mM | 0.0919 mL | 0.4594 mL | 0.9188 mL | 2.2969 mL | |
| 50 mM | 0.0735 mL | 0.3675 mL | 0.7350 mL | 1.8376 mL | |
| 60 mM | 0.0613 mL | 0.3063 mL | 0.6125 mL | 1.5313 mL | |
| 80 mM | 0.0459 mL | 0.2297 mL | 0.4594 mL | 1.1485 mL | |
| 100 mM | 0.0368 mL | 0.1838 mL | 0.3675 mL | 0.9188 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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