1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. 2-Methylcitric acid trisodium

2-Methylcitric acid trisodium (Synonyms: Methylcitric acid trisodium)

Cat. No.: HY-113371A
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2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate.

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2-Methylcitric acid trisodium Chemical Structure

2-Methylcitric acid trisodium Chemical Structure

CAS No. : 117041-96-0

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Description

2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

2-Methylcitric acid trisodium impairs glutamate metabolism and induces permeability transition in brain mitochondria[1].
2-Methylcitric acid trisodium inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM[1].
2-Methylcitric acid trisodium (1 mM, 3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca2+-loaded mitochondria supported by different substrates[1].
2-Methylcitric acid trisodium behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis[1].
2-Methylcitric acid trisodium does not significantly impair mitochondrial glutamate transport[1].
2-Methylcitric acid trisodium does not significantly impair glutamate mitochondrial transport in liver mitochondria[1].

Molecular Weight

272.10

Formula

C₇H₇Na₃O₇

CAS No.

117041-96-0

SMILES

CC(C(O[Na])=O)C(C(O[Na])=O)(O)CC(O[Na])=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

2-Methylcitric acid trisodiumMethylcitric acid trisodiumEndogenous MetabolitemethylmalonicpropionicacidemiasInhibitorinhibitorinhibit

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2-Methylcitric acid trisodium
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