1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. 2-Methylcitric acid

2-Methylcitric acid (Synonyms: Methylcitric acid)

Cat. No.: HY-113371
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2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate.

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2-Methylcitric acid Chemical Structure

2-Methylcitric acid Chemical Structure

CAS No. : 6061-96-7

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Description

2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

2-Methylcitric acid (Methylcitric acid) impairs glutamate metabolism and induces permeability transition in brain mitochondria. 2-Methylcitric acid inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM[1].
2-Methylcitric acid (1-3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca2+-loaded mitochondria supported by different substrates[1].
2-Methylcitric acid behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis. 2-Methylcitric acid does not significantly impair mitochondrial glutamate transport. 2-Methylcitric acid does not significantly impair glutamate mitochondrial transport in liver mitochondria[1].

Molecular Weight

206.15

Formula

C₇H₁₀O₇

CAS No.

6061-96-7

SMILES

CC(C(O)=O)C(C(O)=O)(O)CC(O)=O

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Keywords:

2-Methylcitric acidMethylcitric acidEndogenous MetabolitemarkermetaboliteADP-stimulateduncoupledrespirationmitochondriaglutamateInhibitorinhibitorinhibit

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2-Methylcitric acid
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