2-Methylcitric acid-d3
Based on 1 Customer Validation
2-Methylcitric acid-d3 is the deuterium labeled 2-Methylcitric acid. 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.90%
- CAS 番号: 146764-58-1
- 分子式: C7H7D3O7
- 分子量:209.17
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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CAS 番号 146764-58-1
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非標識Cas 6061-96-7
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性状 Solid
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分子量 209.17
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分子式 C7H7D3O7
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Color White to off-white
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SMILES
[2H]C([2H])([2H])C(C(O)=O)C(C(O)=O)(O)CC(O)=O
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別名
Methylcitric acid-d3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
H2O : 100 mg/mL (478.08 mM; Need ultrasonic)
DMSO : 100 mg/mL (478.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Palacios S, et al. Propionyl Coenzyme A Is a Common Intermediate in the 1,2-Propanediol and Propionate Catabolic Pathways Needed for Expression of the prpBCDE Operon during Growth of Salmonella enterica on 1,2-Propanediol. J Bacteriol. 2003 May;185(9):2802-10. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 4.7808 mL | 23.9040 mL | 47.8080 mL | 119.5200 mL |
| 5 mM | 0.9562 mL | 4.7808 mL | 9.5616 mL | 23.9040 mL | |
| 10 mM | 0.4781 mL | 2.3904 mL | 4.7808 mL | 11.9520 mL | |
| 15 mM | 0.3187 mL | 1.5936 mL | 3.1872 mL | 7.9680 mL | |
| 20 mM | 0.2390 mL | 1.1952 mL | 2.3904 mL | 5.9760 mL | |
| 25 mM | 0.1912 mL | 0.9562 mL | 1.9123 mL | 4.7808 mL | |
| 30 mM | 0.1594 mL | 0.7968 mL | 1.5936 mL | 3.9840 mL | |
| 40 mM | 0.1195 mL | 0.5976 mL | 1.1952 mL | 2.9880 mL | |
| 50 mM | 0.0956 mL | 0.4781 mL | 0.9562 mL | 2.3904 mL | |
| 60 mM | 0.0797 mL | 0.3984 mL | 0.7968 mL | 1.9920 mL | |
| 80 mM | 0.0598 mL | 0.2988 mL | 0.5976 mL | 1.4940 mL | |
| 100 mM | 0.0478 mL | 0.2390 mL | 0.4781 mL | 1.1952 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
2-Methylcitric acid-d3 関連分類
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