Oseltamivir acid hydrochloride (Synonyms: GS 4071 hydrochloride; Ro 64-0802 hydrochloride; Oseltamivir carboxylate hydrochloride)

Name: Oseltamivir acid hydrochloride
Brand: MedChemExpress
SKU: HY-13318A
Rating: 5.0 (75 reviews)

Cat. No.: HY-13318A Purity: 99.41%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Oseltamivir acid hydrochloride is an active metabolite of the antiviral agent Oseltamivir (HY-13317) ethylester. Oseltamivir acid hydrochloride belongs to baseline toxicants in toxicity ratio analysis.

For research use only. We do not sell to patients.

CAS No. : 1415963-60-8

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Based on 75 publication(s) in Google Scholar

Other Forms of Oseltamivir acid hydrochloride:

75 Publications Citing Use of MCE Oseltamivir acid hydrochloride

Cell Proliferation/Viability Assay

: Oseltamivir acid hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Jan:97:385-394. [Abstract]; The inhibitory effects of OA on M1 protein synthesis and in three different infection protocols. M1 protein expression in H1N1-infected MDCK cells analyzed by Western blot 24 h post infection.

: Oseltamivir acid hydrochloride purchased from MedChemExpress. Usage Cited in: Antiviral Res. 2016 May:129:81-92. [Abstract]; MDCK cells are infected with K435E or H274Y in the absence of compounds and maintained at 35 °C in agarose with or without 10 nM Oseltamivir or 20 μg/mL D35, respectively.

: Oseltamivir acid hydrochloride purchased from MedChemExpress. Usage Cited in: PLoS One. 2016 May 27;11(5):e0156400. [Abstract]; Live-cell fluorescence imaging of infected cells of Oseltamivir-resistant virus. MDCK cells are infected with Oseltamivir-resistant 738 and -sensitive 838. After incubation at 37°C for 12 hr, the cells are incubated with BTP3-Neu5Ac with or without Oseltamivir or Zanamivir (each 100 nM for final concentrations) in an SFM at 37°C for 10 min. Fluorescent images of the cells are observed under UV irradiation by using a fluorescence microscope. A scale bar indicates 200 μm.

: Oseltamivir acid hydrochloride purchased from MedChemExpress. Usage Cited in: Antiviral Res. 2014 Nov;111:69-77. [Abstract]; Plaque formation of different recombinant viruses in the presence of oseltamivir. MDCK cells are infected with recombinant viruses in the absence of Oseltamivir or DS and maintained in agarose overlay medium with 50 nM Oseltamivir or 100 μg/mL DS (DS), or without compounds (None) at 35 °C.

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References
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Description

Molecular Weight

320.81

Formula

C₁₄H₂₅ClN₂O₄

CAS No.

1415963-60-8

Appearance

Solid

Color

White to light brown

SMILES

O=C(O)C1=C[C@H]([C@@H]([C@H](C1)N)NC(C)=O)OC(CC)CC.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (155.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 25 mg/mL (77.93 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1171 mL	15.5855 mL	31.1711 mL
5 mM	0.6234 mL	3.1171 mL	6.2342 mL
10 mM	0.3117 mL	1.5586 mL	3.1171 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (3.90 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (3.90 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.41%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (252 KB)

Handling Instructions (2659 KB)

References

[1]. Escher BI, et al. Mixture toxicity of the antiviral drug Tamiflu((R)) (oseltamivir ethylester) and its active metabolite oseltamivir acid. Aquat Toxicol. 2010 Feb 18;96(3):194-202. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.1171 mL	15.5855 mL	31.1711 mL	77.9277 mL
	5 mM	0.6234 mL	3.1171 mL	6.2342 mL	15.5855 mL
	10 mM	0.3117 mL	1.5586 mL	3.1171 mL	7.7928 mL
	15 mM	0.2078 mL	1.0390 mL	2.0781 mL	5.1952 mL
	20 mM	0.1559 mL	0.7793 mL	1.5586 mL	3.8964 mL
	25 mM	0.1247 mL	0.6234 mL	1.2468 mL	3.1171 mL
	30 mM	0.1039 mL	0.5195 mL	1.0390 mL	2.5976 mL
	40 mM	0.0779 mL	0.3896 mL	0.7793 mL	1.9482 mL
	50 mM	0.0623 mL	0.3117 mL	0.6234 mL	1.5586 mL
	60 mM	0.0520 mL	0.2598 mL	0.5195 mL	1.2988 mL
DMSO	80 mM	0.0390 mL	0.1948 mL	0.3896 mL	0.9741 mL
DMSO	100 mM	0.0312 mL	0.1559 mL	0.3117 mL	0.7793 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Oseltamivir acid hydrochloride Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oseltamivir acid1415963-60-8GS 4071Ro 64-0802Oseltamivir carboxylateGS4071GS-4071Drug Metaboliteantiviraloseltamivir ethylesterbaseline toxicantsInhibitorinhibitorinhibit

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Oseltamivir acid hydrochloride (Synonyms: GS 4071 hydrochloride; Ro 64-0802 hydrochloride; Oseltamivir carboxylate hydrochloride)

Customer Review

Other Forms of Oseltamivir acid hydrochloride:

Oseltamivir acid hydrochloride Related Antibodies

75 Publications Citing Use of MCE Oseltamivir acid hydrochloride

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Oseltamivir acid hydrochloride Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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