Paecilaminol
Paecilaminol is an amino alcohol and NADH-fumarate reductase inhibitor (IC50 = 5.1 μM against Ascaris suum) that also inhibits both helminth and mammalian mitochondrial complexes I and III, exhibiting antifungal, antibacterial, nematocidal, insecticidal, and cancer cell growth-inhibitory activities. Paecilaminol can be used in research on helminth infections.
For research use only. We do not sell to patients.
- CAS No.: 540770-33-0
- Formula: C20H43NO
- Molecular Weight:313.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Description
In Vitro
Paecilaminol inhibits the growth of human cancer cell lines K562, MCF-7, HL-60, and BGC-823 and acts as an NADH-fumarate reductase inhibitor[1].
Paecilaminol (100 μg/mL) exhibits antifungal activity against Aspergillus niger ATCC6275 and Mucor racemosus IFO4581, with an MIC of 100 μg/mL[2].
Paecilaminol (12.5-25 μg/mL) shows antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus, and Mycobacterium smegmatis[2].
Paecilaminol inhibits Ascaris suum NADH-fumarate reductase with an IC50 of 5.1 μM, and this inhibition is not affected by the presence of 30 mg/mL bovine serum albumin[5].
Paecilaminol exhibits nematicidal and insecticidal activities, with a minimum inhibitory concentration for growth of 20 μg/mL against C. elegans and 5 μg/mL against A. salina[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 540770-33-0
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Molecular Weight 313.56
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Formula C20H43NO
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SMILES
CC(N)C(O)CCCCCCCCCCC(C)CC(C)CC
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Synonyms
FKI-0550
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Structure Classification
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Initial Source
Paecilomyces sp.
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Chen W, et al. Secondary Metabolites of Purpureocilliumlilacinum. Molecules. 2021 Dec 21;27(1):18.
[3]. Ui H, et al. Paecilaminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550. J Antibiot (Tokyo). 2006 Sep;59(9):591-6. [Content Brief]
[5]. Ui H, et al. Paecilaminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550. The Journal of antibiotics. 2006 Sep;59(9):591-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Paecilaminol Related Classifications
HY-N10184 Related Classifications
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