1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
    Metabolic Enzyme/Protease
  2. EGFR
    Drug Metabolite
  3. AST5902 trimesylate

AST5902 trimesylate 

Cat. No.: HY-138627A Purity: 99.87%
Handling Instructions

AST5902 trimesylate is the principal metabolite of Alflutinib (AST2818) both in vitro and in vivo. AST5902 trimesylate exerts antineoplastic activity. Alflutinib is an EGFR inhibitor.

For research use only. We do not sell to patients.

AST5902 trimesylate Chemical Structure

AST5902 trimesylate Chemical Structure

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 445 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 445 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
25 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

AST5902 trimesylate is the principal metabolite of Alflutinib (AST2818) both in vitro and in vivo. AST5902 trimesylate exerts antineoplastic activity. Alflutinib is an EGFR inhibitor[1].

IC50 & Target

EGFR[1]

Molecular Weight

842.88

Formula

C₃₀H₄₁F₃N₈O₁₁S₃

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (59.32 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1864 mL 5.9320 mL 11.8641 mL
5 mM 0.2373 mL 1.1864 mL 2.3728 mL
10 mM 0.1186 mL 0.5932 mL 1.1864 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
AST5902 trimesylate
Cat. No.:
HY-138627A
Quantity:
MCE Japan Authorized Agent: