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Cat. No.: HY-138627AR

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AST5902 trimesylate (Standard)

AST5902 trimesylate (Standard) is the analytical standard of AST5902 trimesylate (HY-138627A). This product is intended for research and analytical applications. AST5902 trimesylate is the active metabolite of Furmonertinib (HY-112870) with antitumor activity, and acts as a EGFR inhibitor. AST5902 trimesylate inhibits CYP3A4 mRNA transcription at low concentrations and induces CYP3A4 mRNA expression at high concentrations. AST5902 trimesylate can be used in research related to non-small cell lung cancer.

For research use only. We do not sell to patients.

CAS No.: 2929417-90-1
Formula: C₃₀H₄₁F₃N₈O₁₁S₃
Molecular Weight:842.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AST5902 trimesylate (Standard) Chemical Structure

CAS No.: 2929417-90-1

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 2929417-90-1
Molecular Weight 842.88
Formula C₃₀H₄₁F₃N₈O₁₁S₃
SMILES

CS(=O)(O)=O.C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(C)CCNC)=O.CS(=O)(O)=O.CS(=O)(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Zou HX, et al. Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model. Acta pharmacologica Sinica. 2022 Jul;43(7):1865-1874.

[2]. Liu XY, et al. Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer. Acta pharmacologica Sinica. 2020 Oct;41(10):1366-1376. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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