1. GPCR/G Protein
    Immunology/Inflammation
  2. Histamine Receptor

Cetirizine dihydrochloride (Synonyms: P071)

Cat. No.: HY-17042A Purity: 99.17%
Handling Instructions

Cetirizine 2Hcl, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria.

For research use only. We do not sell to patients.

Cetirizine dihydrochloride Chemical Structure

Cetirizine dihydrochloride Chemical Structure

CAS No. : 83881-52-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
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Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg USD 96 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
500 mg USD 120 In-stock
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Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Other Forms of Cetirizine dihydrochloride:

    Cetirizine dihydrochloride purchased from MCE. Usage Cited in: Pharmacol Res. 2017 Sep 1;125(Pt B):150-160.

    The IL-33 production in different treatment groups is determined in rat skin by immunohistochemistry assay.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Cetirizine 2Hcl, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. IC50 value: Target: Histamine H1 receptor Cetirizine crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines. It has also been shown to inhibit eosinophil chemotaxis and LTB4 release. At a dosage of 20 mg, Boone et al. found that it inhibited the expression of VCAM-1 in patients with atopic dermatitis. The levorotary enantiomer of cetirizine, known as levocetirizine, is the more active form. From Wikipedia.

    Clinical Trial
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 15.5 mg/mL (33.56 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1654 mL 10.8270 mL 21.6539 mL
    5 mM 0.4331 mL 2.1654 mL 4.3308 mL
    10 mM 0.2165 mL 1.0827 mL 2.1654 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    461.81

    Formula

    C₂₁H₂₇Cl₃N₂O₃

    CAS No.

    83881-52-1

    SMILES

    O=C(O)COCCN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1.Cl.Cl

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 99.17%

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Product Name:
    Cetirizine dihydrochloride
    Cat. No.:
    HY-17042A
    Quantity:

    Cetirizine dihydrochloride

    Cat. No.: HY-17042A