1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Cetirizine dihydrochloride

Cetirizine dihydrochloride (Synonyms: P071)

Cat. No.: HY-17042A Purity: 99.17%
Handling Instructions

Cetirizine dihydrochloride, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine dihydrochloride marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

For research use only. We do not sell to patients.

Cetirizine dihydrochloride Chemical Structure

Cetirizine dihydrochloride Chemical Structure

CAS No. : 83881-52-1

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg USD 96 In-stock
Estimated Time of Arrival: December 31
500 mg USD 120 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Cetirizine dihydrochloride:

Top Publications Citing Use of Products

Publications Citing Use of MCE Cetirizine dihydrochloride

    Cetirizine dihydrochloride purchased from MCE. Usage Cited in: Pharmacol Res. 2017 Nov;125(Pt B):150-160.

    The IL-33 production in different treatment groups is determined in rat skin by immunohistochemistry assay.
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    Description

    Cetirizine dihydrochloride, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine dihydrochloride marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

    IC50 & Target

    H1 receptor

     

    In Vitro
    In Vivo
    Clinical Trial
    Molecular Weight

    461.81

    Formula

    C₂₁H₂₇Cl₃N₂O₃

    CAS No.

    83881-52-1

    SMILES

    O=C(O)COCCN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1.Cl.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (216.54 mM; Need ultrasonic)

    H2O : 100 mg/mL (216.54 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1654 mL 10.8270 mL 21.6539 mL
    5 mM 0.4331 mL 2.1654 mL 4.3308 mL
    10 mM 0.2165 mL 1.0827 mL 2.1654 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.41 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.41 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.41 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.17%

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

    Keywords:

    CetirizineP071P 071P-071Histamine ReceptorhistamineSARARIL-1βGM-CSFIL-8SeasonalallergicrhinitisInhibitorinhibitorinhibit

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    Product name:
    Cetirizine dihydrochloride
    Cat. No.:
    HY-17042A
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