1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Cetirizine dihydrochloride

Cetirizine dihydrochloride (Synonyms: P071)

Cat. No.: HY-17042A Purity: 99.17%
Handling Instructions

Cetirizine dihydrochloride, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine dihydrochloride marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response.

For research use only. We do not sell to patients.

Cetirizine dihydrochloride Chemical Structure

Cetirizine dihydrochloride Chemical Structure

CAS No. : 83881-52-1

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Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg USD 96 In-stock
Estimated Time of Arrival: December 31
500 mg USD 120 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Cetirizine dihydrochloride:

Top Publications Citing Use of Products

    Cetirizine dihydrochloride purchased from MCE. Usage Cited in: Pharmacol Res. 2017 Nov;125(Pt B):150-160.

    The IL-33 production in different treatment groups is determined in rat skin by immunohistochemistry assay.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Cetirizine dihydrochloride, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine dihydrochloride marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

    In Vitro

    Cetirizine (>5 μM) at higher concentrations can reduce the release of GM-CSF and IL-8 from A549 cells stimulated with IL-1β. Cetirizine exerts anti-inflammatory effects beyond histamine H1-receptor antagonist[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo
    Clinical Trial
    Molecular Weight

    461.81

    Formula

    C₂₁H₂₇Cl₃N₂O₃

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (216.54 mM; Need ultrasonic)

    H2O : 100 mg/mL (216.54 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1654 mL 10.8270 mL 21.6539 mL
    5 mM 0.4331 mL 2.1654 mL 4.3308 mL
    10 mM 0.2165 mL 1.0827 mL 2.1654 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 120 mg/mL (259.85 mM); Clear solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.41 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.41 mM); Clear solution

    • 4.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.41 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.17%

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    Product Name:
    Cetirizine dihydrochloride
    Cat. No.:
    HY-17042A
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