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Cat. No.: HY-17042B

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(S)-Cetirizine dihydrochloride

Name: (S)-Cetirizine dihydrochloride
Brand: MedChemExpress
SKU: HY-17042B
Price: 441.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: (S)-P071)

(S)-Cetirizine dihydrochloride ((S)-P071) is an orally active antagonist of the histamine H1 receptor with a K_i value of 39.1 nM. (S)-Cetirizine dihydrochloride exerts anti-allergic activity by binding to the histamine H1 receptor and blocking the action of histamine. (S)-Cetirizine dihydrochloride is promising for research of allergic diseases such as allergic rhinitis.

For research use only. We do not sell to patients.

CAS No.: 163837-48-7
Formula: C₂₁H₂₇Cl₃N₂O₃
Molecular Weight:461.81

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

(S)-Cetirizine dihydrochloride Chemical Structure

CAS No.: 163837-48-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

H₁ Receptor

39.1 nM (Ki)

All Histamine Receptor Isoforms :

Chemical Information

CAS No. 163837-48-7
Molecular Weight 461.81
Formula C₂₁H₂₇Cl₃N₂O₃
SMILES

OC(COCCN(CC1)CCN1[C@@H](C2=CC=CC=C2)C3=CC=C(C=C3)Cl)=O.Cl.Cl
Synonyms

(S)-P071
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hishinuma S, et al. Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (S)-Cetirizine by Lys191 in Human Histamine H₁ Receptors. Int J Mol Sci. 2018 Dec 15;19(12):4067. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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