1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. PPAR
    Drug Metabolite
  3. Clofibric acid

Clofibric acid (Synonyms: Chlorofibrinic acid)

Cat. No.: HY-B1415 Purity: 99.90%
Handling Instructions

Clofibric acid (Chlorofibrinic acid), the pharmaceutically active metabolite of lipid regulators Clofibrate, Etofibrate and Etofyllinclofibrate, is a PPARα agonist which exhibits hypolipidemic effects. Clofibric acid also is an herbicide.

For research use only. We do not sell to patients.

Clofibric acid Chemical Structure

Clofibric acid Chemical Structure

CAS No. : 882-09-7

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
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Description

Clofibric acid (Chlorofibrinic acid), the pharmaceutically active metabolite of lipid regulators Clofibrate, Etofibrate and Etofyllinclofibrate, is a PPARα agonist which exhibits hypolipidemic effects. Clofibric acid also is an herbicide[1][2][3].

IC50 & Target

PPARα[1]

Molecular Weight

214.65

Formula

C₁₀H₁₁ClO₃

CAS No.

882-09-7

SMILES

CC(C)(OC1=CC=C(Cl)C=C1)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (465.87 mM)

H2O : 1 mg/mL (4.66 mM; ultrasonic and warming and heat to 80°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6587 mL 23.2937 mL 46.5875 mL
5 mM 0.9317 mL 4.6587 mL 9.3175 mL
10 mM 0.4659 mL 2.3294 mL 4.6587 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.65 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.65 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.65 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Clofibric acidChlorofibrinic acidPPARDrug MetabolitePeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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Clofibric acid
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HY-B1415
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