Allotetrahydrocortisol-d5
Allotetrahydrocortisol-d5 is the deuterium labeled Allotetrahydrocortisol. Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Cortisol is the main glucocorticoid in human. It is produced in adrenal cortex and plays a crucial role in many physiological processes.
For research use only. We do not sell to patients.
- CAS No.: 2687961-06-2
- Formula: C21H29D5O5
- Molecular Weight:371.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2687961-06-2
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Unlabeled Cas 302-91-0
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Molecular Weight 371.52
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Formula C21H29D5O5
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SMILES
C[C@@]12[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])CC[C@@]4([H])C([2H])([2H])[C@@](O)([2H])C([2H])([2H])C[C@]4(C)[C@@]3([H])[C@@H](O)C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. BUSH IE, et al. The excretion of allo tetrahydrocortisol in human urine. Biochem J. 1957 Dec;67(4):689-700. [Content Brief]
[3]. Kosicka K, et al. Detailed analysis of cortisol, cortisone and their tetrahydro- and allo-tetrahydrometabolites in human urine by LC-MS/MS. J Pharm Biomed Anal. 2017 Jun 5;140:174-181. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Allotetrahydrocortisol-d5 Related Classifications
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