Imidazoleacetic acid hydrochloride (Synonyms: Imidazolyl-4-acetic acid hydrochloride)

Name: Imidazoleacetic acid hydrochloride
Brand: MedChemExpress
SKU: HY-W007686
Rating: 4.5 (1 reviews)

Cat. No.: HY-W007686 Purity: 99.20%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

2-(1H-Imidazol-5-yl)acetic acid hydrochloride is an endogenous metabolite.

For research use only. We do not sell to patients.

Imidazoleacetic acid hydrochloride Chemical Structure

CAS No. : 3251-69-2

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Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 88	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	USD 88	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Imidazoleacetic acid hydrochloride:

Imidazoleacetic acid Get quote

1 Publications Citing Use of MCE Imidazoleacetic acid hydrochloride

•FASEB J. 2022 May;36(5):e22305. [Abstract]

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Biological Activity
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References
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Description

2-(1H-Imidazol-5-yl)acetic acid hydrochloride is an endogenous metabolite.

Molecular Weight

162.57

Formula

C₅H₇ClN₂O₂

CAS No.

3251-69-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)CC1=CN=CN1.[H]Cl

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (615.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (307.56 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.1512 mL	30.7560 mL	61.5120 mL
5 mM	1.2302 mL	6.1512 mL	12.3024 mL
10 mM	0.6151 mL	3.0756 mL	6.1512 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (15.38 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (15.38 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (615.12 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.65%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (249 KB) HNMR (119 KB) RP-HPLC (148 KB)

Handling Instructions (2659 KB)

References

[1]. Prell GD, et al. Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13677-82. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	6.1512 mL	30.7560 mL	61.5120 mL	153.7799 mL
	5 mM	1.2302 mL	6.1512 mL	12.3024 mL	30.7560 mL
	10 mM	0.6151 mL	3.0756 mL	6.1512 mL	15.3780 mL
	15 mM	0.4101 mL	2.0504 mL	4.1008 mL	10.2520 mL
	20 mM	0.3076 mL	1.5378 mL	3.0756 mL	7.6890 mL
	25 mM	0.2460 mL	1.2302 mL	2.4605 mL	6.1512 mL
	30 mM	0.2050 mL	1.0252 mL	2.0504 mL	5.1260 mL
	40 mM	0.1538 mL	0.7689 mL	1.5378 mL	3.8445 mL
	50 mM	0.1230 mL	0.6151 mL	1.2302 mL	3.0756 mL
	60 mM	0.1025 mL	0.5126 mL	1.0252 mL	2.5630 mL
	80 mM	0.0769 mL	0.3844 mL	0.7689 mL	1.9222 mL
	100 mM	0.0615 mL	0.3076 mL	0.6151 mL	1.5378 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Imidazoleacetic acid hydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imidazoleacetic acid3251-69-2Imidazolyl-4-acetic acidEndogenous MetaboliteInhibitorinhibitorinhibit

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Imidazoleacetic acid hydrochloride (Synonyms: Imidazolyl-4-acetic acid hydrochloride)

Customer Review

Other Forms of Imidazoleacetic acid hydrochloride:

Imidazoleacetic acid hydrochloride Related Antibodies

1 Publications Citing Use of MCE Imidazoleacetic acid hydrochloride

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Imidazoleacetic acid hydrochloride Related Classifications

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Your Recently Viewed Products:

Customer Review

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