1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. 3,4-Dehydro Cilostazol

3,4-Dehydro Cilostazol (Synonyms: OPC-13015)

Cat. No.: HY-135910
Handling Instructions

3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol (CLZ; HY-17464). 3,4-Dehydro Cilostazol is used for pharmacokinetic study.

For research use only. We do not sell to patients.

3,4-Dehydro Cilostazol Chemical Structure

3,4-Dehydro Cilostazol Chemical Structure

CAS No. : 73963-62-9

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Based on 1 publication(s) in Google Scholar

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Description

3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol (CLZ; HY-17464). 3,4-Dehydro Cilostazol is used for pharmacokinetic study[1].

In Vivo

3,4-Dehydro Cilostazol (OPC-13015; Oral; 1 mg/kg GLZ and 10 mg/kg CLZ) has a T1/2 of 3.94 hours, a Cmax of 1.39 μM and an AUC0-24 of 4.69 μg•h/ml. The plasma concentration time profiles of GLZ, CLZ & its active metabolite DCLZ are traceable up to 24 h, 12 h and 12 h respectively by oral administration at 1 mg/kg dose of GLZ and 10 mg/kg CLZ[1].

Animal Model: Male Wistar rats weighing 200 g[1]
Dosage: 1 mg/kg Glipizide (GLZ) and 10 mg/kg Cilostazol (CLZ) (Pharmacokinetic Analysis)
Administration: Oral
Result: Had a T1/2 of 3.94 hours, a Cmax of 1.39 μM and an AUC0-24 of 4.69 μg•h/ml.
Molecular Weight

367.44

Formula

C₂₀H₂₅N₅O₂

CAS No.

73963-62-9

SMILES

O=C1NC2=C(C=C(OCCCCC3=NN=NN3C4CCCCC4)C=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (13.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7215 mL 13.6077 mL 27.2153 mL
5 mM 0.5443 mL 2.7215 mL 5.4431 mL
10 mM 0.2722 mL 1.3608 mL 2.7215 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

3,4-Dehydro CilostazolOPC-13015OPC13015OPC 13015Drug MetabolitecilostazolpharmacokineticglipizideInhibitorinhibitorinhibit

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3,4-Dehydro Cilostazol
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HY-135910
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