1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. Fomepizole hydrochloride

Fomepizole hydrochloride (Synonyms: 4-Methylpyrazole hydrochloride)

Cat. No.: HY-B0876A
Handling Instructions

Fomepizole (4-Methylpyrazole) hydrochloride is a potent and orally active cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning.

For research use only. We do not sell to patients.

Fomepizole hydrochloride Chemical Structure

Fomepizole hydrochloride Chemical Structure

CAS No. : 56010-88-9

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2 Publications Citing Use of MCE Fomepizole hydrochloride

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Description

Fomepizole (4-Methylpyrazole) hydrochloride is a potent and orally active cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning[1][2][3].

IC50 & Target

CYP2E1

 

In Vivo

Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice[4]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-1 mice weighing 18-25 g[4]
Dosage: 25 mg/kg
Administration: IP; single dose
Result: Decreased the dose of ethanol (1-5 g/kg; IP) at which 50% of the animals failed a particular outcome test (toxic dose 50; TD50).
Molecular Weight

118.56

Formula

C4H7ClN2

CAS No.
SMILES

CC1=CNN=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
Fomepizole hydrochloride
Cat. No.:
HY-B0876A
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