Fomepizole hydrochloride
Based on 4 publication(s) in Google Scholar
Fomepizole (4-Methylpyrazole) hydrochloride is a potent and orally active cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning.
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- Pureté : 99.85%
- CAS No.: 56010-88-9
- Formule: C4H7ClN2
- Masse moléculaire:118.56
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Fomepizole hydrochloride
More
Customer Validation & Images
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
Activité biologique
Description
IC50 & Target
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CYP2E1 |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CD-1 mice weighing 18-25 g[4]
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Dosage:25 mg/kg
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Administration:IP; single dose
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Result:Decreased the dose of ethanol (1-5 g/kg; IP) at which 50% of the animals failed a particular outcome test (toxic dose 50; TD50).
Chemical Information
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CAS No. 56010-88-9
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Appearance Liquid
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Masse moléculaire 118.56
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Formule C4H7ClN2
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Color Purple to purplish red
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SMILES
CC1=CNN=C1.Cl
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Synonyms
4-Methylpyrazole hydrochloride
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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Plant Physiol
Symbiosis between Dendrobium catenatum protocorms and Serendipita indica involves the plant hypoxia response pathway. [Abstract]2023 Jul 3;192(3):2554-2568. PMID: 36988071
Fomepizole hydrochloride purchased from MedChemExpress. Usage Cited in: Plant Physiol. 2023 Jul 3;192(3):2554-2568. [Abstract]
The ADH inhibitors 4-methylpyrazole inhibits the NADH-converting activities of DcADH1 and DcADH2 in vitro.
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Anal Chem
A Computational Integration Strategy Driven by Chemical Similarity Uncovers Comprehensive Metabolic Profiles of Small Bioactive Peptides via UHPLC-HRMS for Doping Control. [Abstract]2025 Nov 18;97(45):25158-25167. PMID: 41202118 -
Food Chem Toxicol
The "steric-like" inhibitory effect and mechanism of doxycycline on florfenicol metabolism: Interaction risk. [Abstract]2022 Nov:169:113431. PMID: 36116547
Fomepizole hydrochloride purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2022 Nov:169:113431. [Abstract]
The influence of specific inhibitors of CYP450 [sulphaphenazole (CYP2C9 inhibitor), quinidine (CYP2D6 inhibitor), fomepizole (CYP2E1 inhibitor), methoxsalen (CYP2A6 inhibitor), diosmetin (CYP1A inhibitor) and ketoconazol (CYP3A4 inhibitor)] on the generation of FFA.
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Chemosphere
A proposed "steric-like effect" for the slowdown of enrofloxacin antibiotic metabolism by ciprofloxacin, and its mechanism. [Abstract]2021 Dec:284:131347. PMID: 34323809
Solvant et solubilité
In Vitro:
DMSO : 350 mg/mL (2952.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 350 mg/mL (2952.09 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Casavant MJ. Fomepizole in the treatment of poisoning. Pediatrics. 2001 Jan;107(1):170. [Content Brief]
[2]. Lepik KJ, et al. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. Ann Emerg Med. 2009 Apr;53(4):439-450.e10. [Content Brief]
[4]. Páez AM, et al. Effects of 4-methylpyrazole on ethanol neurobehavioral toxicity in CD-1 mice. Acad Emerg Med. 2004 Aug;11(8):820-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 8.4345 mL | 42.1727 mL | 84.3455 mL | 210.8637 mL |
| 5 mM | 1.6869 mL | 8.4345 mL | 16.8691 mL | 42.1727 mL | |
| 10 mM | 0.8435 mL | 4.2173 mL | 8.4345 mL | 21.0864 mL | |
| 15 mM | 0.5623 mL | 2.8115 mL | 5.6230 mL | 14.0576 mL | |
| 20 mM | 0.4217 mL | 2.1086 mL | 4.2173 mL | 10.5432 mL | |
| 25 mM | 0.3374 mL | 1.6869 mL | 3.3738 mL | 8.4345 mL | |
| 30 mM | 0.2812 mL | 1.4058 mL | 2.8115 mL | 7.0288 mL | |
| 40 mM | 0.2109 mL | 1.0543 mL | 2.1086 mL | 5.2716 mL | |
| 50 mM | 0.1687 mL | 0.8435 mL | 1.6869 mL | 4.2173 mL | |
| 60 mM | 0.1406 mL | 0.7029 mL | 1.4058 mL | 3.5144 mL | |
| 80 mM | 0.1054 mL | 0.5272 mL | 1.0543 mL | 2.6358 mL | |
| 100 mM | 0.0843 mL | 0.4217 mL | 0.8435 mL | 2.1086 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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