56010-88-9
Chemical Structure
Fomepizole hydrochloride
Synonym(s): 4-Methylpyrazole hydrochloride
- CAS No.: 56010-88-9
- Formula:C4H7ClN2
- Molecular Weight:118.56
IUPAC Name: 4-methyl-1H-pyrazole hydrochloride
InChIKey: PUCXJHNDMYZOHG-UHFFFAOYSA-N
SMILES: CC1=CNN=C1.Cl
Biological Activity: Fomepizole (4-Methylpyrazole) hydrochloride is a potent and orally active cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning[1][2][3].
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Fomepizole hydrochloride | 99.85% | Fomepizole (4-Methylpyrazole) hydrochloride is a potent and orally active cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning. | ||||||||||||||||||||
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- [1]. Casavant MJ. Fomepizole in the treatment of poisoning. Pediatrics. 2001 Jan;107(1):170. [Content Brief]
- [2]. Lepik KJ, et al. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. Ann Emerg Med. 2009 Apr;53(4):439-450.e10. [Content Brief]
- [3]. Garrett Rampon, et al. Use of fomepizole as an adjunct in the treatment of acetaminophen overdose: a case series. Toxicology Communications. Volume 4, 2020 - Issue 1.
Keywords
