1. Anti-infection
    Cell Cycle/DNA Damage
  2. HBV
    DNA/RNA Synthesis
  3. LB80317

LB80317 

Cat. No.: HY-106235
Handling Instructions

LB80317 is an active metabolite of LB80380 and suppresses the DNA synthesis of HBV with an EC50 of 0.5 μM. LB80317 has antiviral effect and has the potential for chronic hepatitis B treatment.

For research use only. We do not sell to patients.

LB80317 Chemical Structure

LB80317 Chemical Structure

CAS No. : 441785-24-6

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Description

LB80317 is an active metabolite of LB80380 and suppresses the DNA synthesis of HBV with an EC50 of 0.5 μM. LB80317 has antiviral effect and has the potential for chronic hepatitis B treatment[1][2].

IC50 & Target

EC50: 0.5 μM (DNA synthesis of HBV)[2]

In Vitro

After phosphorylation to di- and triphosphate forms, LB80317 is incorporated into the viral DNA inside the nucleocapsid, which inhibits further DNA synthesis. In in vitro studies using cell line models, the drug concentrations causing 50% reduction in HBV DNA produced (EC50) is 0.5 μM for LB80317[2].

In Vivo

Forty percent of the amount of LB80331/LB80317 in the mouse liver is detected as the phosphorylated form. LB80380 is rapidly absorbed and converted to LB80331. LB80317 has a long half-life at steady-state (T1/2=8.3-9.9 hours)[1].

Molecular Weight

315.22

Formula

C₁₀H₁₄N₅O₅P

CAS No.

441785-24-6

SMILES

OP(O)(COC1(CN2C=NC3=C2N=C(N)NC3=O)CC1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

LB80317LB 80317LB-80317HBVDNA/RNA SynthesisHepatitis B virusAntiviralldehydeoxidasexanthineCHBnucleotideGMPInhibitorinhibitorinhibit

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LB80317
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