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Results for "

xanthine

" in MCE Product Catalog:

By Targets:	Xanthine Oxidase (45) Adenosine Receptor (8) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (3) Bacterial (2) COX (1) Cytochrome P450 (2) DNA/RNA Synthesis (1) Drug Metabolite (8) Drug-Linker Conjugates for ADC (1) Endogenous Metabolite (13) Ferroptosis (1) HBV (1) HIV (1) Influenza Virus (1) Isotope-Labeled Compounds (1) Lipoxygenase (1) NADPH Oxidase (1) NF-κB (1) NO Synthase (1) Nucleoside Antimetabolite/Analog (7) Parasite (1) Phosphodiesterase (PDE) (3) PI3K (1) Protein Arginine Deiminase (1) Reactive Oxygen Species (2) Reverse Transcriptase (1) TNF Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (19) Cardiovascular Disease (6) Endocrinology (1) Infection (11) Inflammation/Immunology (24) Metabolic Disease (31) Neurological Disease (10)

By Targets:

Xanthine Oxidase (45)

Adenosine Receptor (8)

Angiotensin-converting Enzyme (ACE) (1)

Apoptosis (3)

Bacterial (2)

COX (1)

Cytochrome P450 (2)

DNA/RNA Synthesis (1)

Drug Metabolite (8)

Drug-Linker Conjugates for ADC (1)

Endogenous Metabolite (13)

Ferroptosis (1)

HBV (1)

HIV (1)

Influenza Virus (1)

Isotope-Labeled Compounds (1)

Lipoxygenase (1)

NADPH Oxidase (1)

NF-κB (1)

NO Synthase (1)

Nucleoside Antimetabolite/Analog (7)

Parasite (1)

Phosphodiesterase (PDE) (3)

PI3K (1)

Protein Arginine Deiminase (1)

Reactive Oxygen Species (2)

Reverse Transcriptase (1)

TNF Receptor (1)

Toll-like Receptor (TLR) (1)

By Research Areas:

Cancer (19)

Cardiovascular Disease (6)

Endocrinology (1)

Infection (11)

Inflammation/Immunology (24)

Metabolic Disease (31)

Neurological Disease (10)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Xanthine Oxidase

Cat. No.	Product Name	Target	Research Areas

HY-W017389

*Xanthine*	Endogenous Metabolite	Inflammation/Immunology
Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation.

HY-P2755

Xanthine oxidase	Reactive Oxygen Species	Endocrinology Inflammation/Immunology
Xanthine oxidase is a xanthine oxidoreductase enzyme that generates reactive oxygen species (ROS), catalyzes the oxidation of hypoxanthine to xanthine, and further catalyzes the oxidation of xanthine to uric acid.

HY-151974

Xanthine oxidoreductase-IN-4	Xanthine Oxidase	Metabolic Disease
Xanthine oxidoreductase-IN-4 is an orally active xanthine oxidoreductase (XOR) inhibitor. Xanthine oxidoreductase-IN-4 has inhibitory activity against XOR with an IC₅₀ value of 29.3 nM. Xanthine oxidoreductase-IN-4 can be used for the research of hyperuricemia.

HY-151975

Xanthine oxidoreductase-IN-5	Xanthine Oxidase	Metabolic Disease
Xanthine oxidoreductase-IN-5 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC₅₀ of 55 nM. Xanthine oxidoreductase-IN-5 can be used for the research of acute hyperuricemia.

HY-151973

Xanthine oxidoreductase-IN-3	Xanthine Oxidase	Metabolic Disease
Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC₅₀ of 26.3 nM. Xanthine oxidoreductase-IN-3 can be used for the research of acute hyperuricemia.

HY-146297

Xanthine oxidoreductase-IN-2	Xanthine Oxidase	Metabolic Disease
Xanthine oxidoreductase-IN-2 (Compound IVa) is a xanthine oxidoreductase (XOR) inhibitor with the IC₅₀ of 7.2 nM. Xanthine oxidoreductase-IN-2 shows hypouricemic effects in mice.

HY-N10432

Xanthine oxidase-IN-8
Icarisids J
Xanthine Oxidase Metabolic Disease

Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) is a XOD inhibitor with an IC₅₀ of 29.71 μM.

Xanthine oxidase-IN-8 Icarisids J	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) is a XOD inhibitor with an IC₅₀ of 29.71 μM.

HY-146273

Xanthine oxidase-IN-7	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-7 (compound1h) is a potent andorally active *XO (xanthine* oxidase) inhibitor with an IC₅₀** of 0.36 µM. Xanthine oxidase-IN-7 effectively reduces serum uric acid levels. Xanthine oxidase-IN-7 has the potential for the research of hyperuricemia and gout.

HY-144303

Xanthine oxidase-IN-4	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent xanthine oxidase (XO) inhibitor, with an IC₅₀ of 0.039 μM. Xanthine oxidase-IN-4 exhibits hypouricemic potency in potassium oxonate induced hyperuricemia rats. Xanthine oxidase-IN-4 can be used for hyperuricemia and gout research.

HY-101139A

Xanthine amine congener hydrochloride XAC hydrochloride	Adenosine Receptor	Neurological Disease
Xanthine amine congener (XAC) hydrochloride is a non-selective adenosine receptor antagonist. Xanthine amine congener hydrochloride induces convulsions in mice.

HY-101139

Xanthine amine congener XAC	Adenosine Receptor	Neurological Disease
Xanthine amine congener is a non-selective adenosine receptor antagonist. Xanthine amine congener induces convulsions in mice.

HY-146560

Xanthine oxidase-IN-6	Xanthine Oxidase NF-κB Toll-like Receptor (TLR) TNF Receptor	Metabolic Disease Inflammation/Immunology
Xanthine oxidase-IN-6 (Compound 6c) is a potent, orally active, mixed-type xanthine oxidase (XOD) inhibitor with an IC₅₀ value of 1.37 µM. Xanthine oxidase-IN-6 shows strong anti-hyperuricemia and renal protective activity.

HY-144456

Xanthine oxidase-IN-5	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-5 is an effective and orally active xanthine oxidase (XO) inhibitor with IC₅₀ value of 0.70 μM. Xanthine oxidase-IN-5 displays favorable agent-like properties with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Xanthine oxidase-IN-5 shows potent hypouricemic effects in hyperuricemic rat model.

HY-N10433

Xanthine oxidase-IN-9 Icarisids E	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-9 (Icarisids E) (Compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC₅₀ of 31.81 μM.

HY-110303

Xanthine amine congener dihydrochloride XAC dihydrochloride	Adenosine Receptor	Neurological Disease
Xanthine amine congener dihydrochloride (XAC dihydrochloride) is a potent Adenosine A1 receptor and A2 receptor antagonist with IC₅₀ values of 1.8 and 114 nM, respectively. Xanthine amine congener acts as a convulsant agent in mice model.

HY-146296

Xanthine oxidoreductase-IN-1	Xanthine Oxidase	Metabolic Disease
The compound is a xanthine oxidoreductase (XOR) inhibitor with high inhibitory concentration, and the value of ic₅₀ is 7.0 nm.

HY-U00288

Xanthine oxidase-IN-1 4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acid	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-1 is a xanthine oxidase inhibitor extracted from patent WO2008126898A1, page 68, compound example 3, with an IC₅₀ of 6.5 nM.

HY-W017389S

Xanthine-13C,15N2	Drug-Linker Conjugates for ADC	Cancer
Xanthine- 13C,¹⁵N₂ is a ¹⁵N-labeled and ¹³C-labled Deruxtecan. Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and amaleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

HY-N7397

Forsythoside F
Arenarioside
Xanthine Oxidase Metabolic Disease

Forsythoside F (Arenarioside) is a xanthine oxidase inhibitor and possesses antihyperuricemic effects in vivo.
HY-131267

Febuxostat sec-butoxy acid
Drug Metabolite Others

Febuxostat sec-butoxy acid is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.
HY-131269

Febuxostat impurity 7
Drug Metabolite Others

Febuxostat impurity 7 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.
HY-131273

Febuxostat amide impurity
Drug Metabolite Others

Febuxostat amide impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM
HY-131270

Febuxostat impurity 8
Drug Metabolite Others

Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.
HY-131253

Febuxostat isopropyl isomer
Drug Metabolite Others

Febuxostat isopropyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.
HY-131271

Febuxostat impurity 6
Drug Metabolite Others

Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

Forsythoside F Arenarioside	Xanthine Oxidase	Metabolic Disease
Forsythoside F (Arenarioside) is a xanthine oxidase inhibitor and possesses antihyperuricemic effects in vivo.

Febuxostat sec-butoxy acid	Drug Metabolite	Others
Febuxostat sec-butoxy acid is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

Febuxostat impurity 7	Drug Metabolite	Others
Febuxostat impurity 7 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

Febuxostat amide impurity	Drug Metabolite	Others
Febuxostat amide impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM

Febuxostat impurity 8	Drug Metabolite	Others
Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

Febuxostat isopropyl isomer	Drug Metabolite	Others
Febuxostat isopropyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

Febuxostat impurity 6	Drug Metabolite	Others
Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

HY-131272

Febuxostat dicarboxylic acid impurity	Drug Metabolite	Others
Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

HY-131266

Febuxostat n-butyl isomer
Drug Metabolite Others

Febuxostat n-butyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

Febuxostat n-butyl isomer	Drug Metabolite	Others
Febuxostat n-butyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

HY-106506

Desciclovir BW A515U	Others	Infection
Desciclovir is a potent and orally active proagent of the antiherpetic agent Acyclovir (ACV). Desciclovir is converted to acyclovir in vivo by xanthine oxidase.

HY-139585

Tigulixostat LC350189	Xanthine Oxidase	Metabolic Disease
Tigulixostat (LC350189) is an orally active, non-purine selective xanthine oxidase inhibitor. Tigulixostat lowers the production of uric acid. Tigulixostat can be used for gout and hyperuricemia study.

HY-N10741

Ellagic acid 4-O-β-D-xylopyranoside	Xanthine Oxidase Bacterial	Infection
Ellagic acid 4-O-β-D-xylopyranoside is a natural ellagitannin with antimicrobial activity. Ellagic acid 4-O-β-D-xylopyranoside is an xanthine oxidase inhibitor with an ₅₀ of 2.1 μg/mL.

HY-W041301

(±)-Dihydroactinidiolide	Others	Others
(±)-Dihydroactinidiolide, an important aroma compound of black tea and tobacco, has been isolated from several plants. (±)-Dihydroactinidiolide can be formation from β-Carotene by the treatment of polyphenoloxidase, the lipoxygenase, and the xanthine oxidase.

HY-N1162

Tetrahydroamentoflavone Amentoflavanone	Xanthine Oxidase	Infection Inflammation/Immunology
Tetrahydroamentoflavone (Amentoflavanone) is a potent xanthine oxidase (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC₅₀ and K_i values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout.

HY-N0327

Lobetyolin	Apoptosis Xanthine Oxidase	Metabolic Disease
Lobetyolin, a bioactive compound, is derived from Codonopsis pilosula. Lobetyolin has anti-inflammatory, anti-oxidative and xanthine oxidase inhibiting activities. Lobetyolin also induces the apoptosis via the inhibition of ASCT2-mediated glutamine metabolism.

HY-Y1250S5

Fmoc-Gly-OH-13C2	Isotope-Labeled Compounds Endogenous Metabolite	Inflammation/Immunology
Fmoc-Gly-OH-¹³C₂ is a ¹³C-labeled Xanthine. Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation[1][2][3].

HY-79128S

Fmoc-L-Lys (Boc)-OH-15N2	Endogenous Metabolite	Inflammation/Immunology
Fmoc-L-Lys (Boc)-OH-¹⁵N₂ is a ¹⁵N-labeled Xanthine. Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation[1][2][3].

HY-N9330

Broussoflavonol F
Xanthine Oxidase Others

Broussoflavonol F possess xanthine oxidase inhibitory activity.
HY-W017163

7-Methylxanthine
Endogenous Metabolite Metabolic Disease

7-Methylxanthine, a methyl derivative of xanthine, is one of the purine components in urinary calculi.

Broussoflavonol F	Xanthine Oxidase	Others
Broussoflavonol F possess xanthine oxidase inhibitory activity.

7-Methylxanthine	Endogenous Metabolite	Metabolic Disease
7-Methylxanthine, a methyl derivative of xanthine, is one of the purine components in urinary calculi.

HY-N0196

Baicalein 5,6,7-Trihydroxyflavone	Xanthine Oxidase Influenza Virus Ferroptosis	Cancer
Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC₅₀ value of 3.12 μM.

HY-N3906

Fraxamoside
Xanthine Oxidase Metabolic Disease

Fraxamoside is a competitive xanthine oxidase inhibitor with an IC₅₀ of 16.1 μM and a K_i of 0.9 μM.
HY-14268S

Febuxostat D9
Xanthine Oxidase Cancer

Febuxostat-d₉ is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with a Ki of 0.6 nM.

Fraxamoside	Xanthine Oxidase	Metabolic Disease
Fraxamoside is a competitive xanthine oxidase inhibitor with an IC₅₀ of 16.1 μM and a K_i of 0.9 μM.

Febuxostat D9	Xanthine Oxidase	Cancer
Febuxostat-d₉ is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with a Ki of 0.6 nM.

HY-B1135

Benzbromarone	Xanthine Oxidase Apoptosis	Metabolic Disease
Benzbromarone is a highly effective and well tolerated non-competitive inhibitor of xanthine oxidase, used as an uricosuric agent, used in the treatment of gout.

HY-131268

O-Desisobutyl-O-n-propyl Febuxostat
Xanthine Oxidase Metabolic Disease

O-Desisobutyl-O-n-propyl Febuxostat, extracted from the patent CN 103467412, is an xanthine oxidase inhibitor.

O-Desisobutyl-O-n-propyl Febuxostat	Xanthine Oxidase	Metabolic Disease
O-Desisobutyl-O-n-propyl Febuxostat, extracted from the patent CN 103467412, is an xanthine oxidase inhibitor.

HY-W011258

H-Tyr-Phe-OH L-Tyrosyl-L-phenylalanine	Xanthine Oxidase Angiotensin-converting Enzyme (ACE)	Cancer Inflammation/Immunology
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells.

HY-50723

3-Methylxanthine	Endogenous Metabolite	Others
3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC₅₀ of 920 μM on guinea-pig isolated trachealis muscle.

HY-14268S1

Febuxostat-d7 TEI 6720-d₇; TMX 67-d₇	Xanthine Oxidase	Metabolic Disease Cancer
Febuxostat-d₇ is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is selective xanthine oxidase inhibitor with a Ki of 0.6 nM[1].

HY-W011527

Xanthosine	Endogenous Metabolite	Others
Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine can increase mammary stem cell population and milk production in cattle and goats.

HY-19657

Oxypurinol Oxipurinol	Endogenous Metabolite Xanthine Oxidase	Metabolic Disease Inflammation/Immunology
Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout.

HY-W013803

Xanthosine dihydrate	Endogenous Metabolite	Metabolic Disease
Xanthosine dihydrate is a nucleoside derived from xanthine and ribose. Xanthosine dihydrate can increase mammary stem cell population and milk production in cattle and goats.

HY-116433

Nequinate	Parasite Xanthine Oxidase	Infection Metabolic Disease
Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections. Nequinate inhibits xanthine oxidoreductase (XOD) activity.

HY-N1547

Prudomestin	Xanthine Oxidase	Inflammation/Immunology
Prudomestin, isolated from the heartwood of Prunus domestica, shows potent xanthine oxidase (XO) inhibitory activity (IC₅₀≈6 µM).

HY-14268A

Febuxostat sodium TEI 6720 sodium; TMX 67 sodium	Xanthine Oxidase	Metabolic Disease Cardiovascular Disease
Febuxostat (TEI 6720) sodium is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a K_i value of 0.6 nM. Febuxostat sodium has the potential for the research of hyperuricemia and gout.

HY-14268

Febuxostat TEI 6720; TMX 67	Xanthine Oxidase	Metabolic Disease Cardiovascular Disease
Febuxostat (TEI 6720) is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a K_i value of 0.6 nM. Febuxostat has the potential for the research of hyperuricemia and gout.

HY-B1505

Acefylline Theophyllineacetic acid; Theophylline-7-acetic acid	Adenosine Receptor Protein Arginine Deiminase Phosphodiesterase (PDE)	Cancer
Acefylline (Theophyllineacetic acid), a xanthine derivative, is an adenosine receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator, which inhibits rat lung cAMP phosphodiesterase isoenzymes.

HY-107203

Propentofylline HWA 285	Phosphodiesterase (PDE)	Inflammation/Immunology Neurological Disease
Propentofylline is a xanthine-derivative that inhibits adenosine uptake and blocks phosphodiesterase activity. Propentofylline has neuroprotective, antiproliferative, and anti-inflammatory effects that improve cognition and dementia severity in patients with Alzheimer's disease or vascular dementia.

HY-N9324

Ilexoside O	Xanthine Oxidase	Inflammation/Immunology
Ilexoside O is a triterpene saponin isolated from the roots of Ilex pubescens. Ilexoside O exhibits weak xanthine oxidase (XOD) inhibitory activity (IC₅₀=53.05 μM).

HY-N10863

Aurantiamide benzoate	Xanthine Oxidase	Infection
Aurantiamide benzoate is a nature product that could be isolated from two tropical medicinal plants, Cunila spicata and Hyptis fasciculata. Aurantiamide benzoate is a potent xanthine oxidase inhiobitor with an IC₅₀ value of 70 μM.

HY-B0219S

Allopurinol-d2	Xanthine Oxidase	Infection Inflammation/Immunology
Allopurinol-d₂ is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM). Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect[1][2].

HY-12136

Purpurogallin	Xanthine Oxidase	Cancer Inflammation/Immunology Cardiovascular Disease
Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent xanthine oxidase (XO) inhibitory activity with an IC₅₀ of 0.2 µM. Purpurogallin has antioxidant and anti-inflammatory effects.

HY-B0128

Diphylline Diprophylline	Adenosine Receptor Phosphodiesterase (PDE)	Inflammation/Immunology Cardiovascular Disease
Diphylline (Diprophylline) is a potent A1/A2 adenosine receptor antagonist and cyclic nucleotide phosphodiesterase inhibitor. Diphylline, a xanthine derivative, is a bronchodilator and vasodilator agent and has the potential for chronic bronchitis and emphysema.

HY-100937

DPCPX PD 116948	Adenosine Receptor	Cardiovascular Disease
DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a K_i of 0.46 nM in ³H-CHA binding to A1 receptors in rat whole brain membranes.

HY-151173

XO/COX/LOX-IN-1	Xanthine Oxidase Lipoxygenase COX	Cancer Metabolic Disease Inflammation/Immunology
XO/COX/LOX-IN-1 (compound 7i) is a potent xanthine oxidase/cyclooxygenases/lipoxygenases (XO/COX/LOX) inhibitor. XO/COX/LOX-IN-1 can be used in studies of inflammation, cancer and metabolic diseases.

HY-N3220

Myricetin 3-O-galactoside	Xanthine Oxidase	Metabolic Disease
Myricetin 3-O-galactoside inhibits xanthine oxidase (XO) activity, lipid peroxidation and scavenges the free radical. Myricetin 3-O-galactoside inhibits lipid peroxidation with an IC₅₀ of 160 μg/mL. Antioxidant activity.

HY-100678

CGS 15943	Adenosine Receptor PI3K	Cancer Inflammation/Immunology
CGS 15943 is an orally bioavailable non-xanthine Adenosine Receptor antagonist. Its K_i for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. .

HY-N2472

Medicagenic acid Castanogenin	Bacterial	Infection
Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes. Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE.

HY-50723S

3-Methylxanthine-13C4,15N3	Endogenous Metabolite	Others
3-Methylxanthine-¹³C₄,¹⁵N₃ is the ¹³C-labeled and ¹⁵N-labeled 3-Methylxanthine. 3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.

HY-N10411

Morin 3-O-β-D-glucopyranoside	Reverse Transcriptase HIV Xanthine Oxidase	Cancer Infection Cardiovascular Disease
Morin 3-O-β-D-glucopyranoside is a natural flavonoid with antifungal, anticancer and antioxidant activities. Morin 3-O-β-D-glucopyranoside inhibits reverse transcriptase, protein-tyrosine kinase and xanthine oxidase, and also shows anti-HIV, antiarteriosclerotic, and superoxide scavenging activities.

HY-14874

Topiroxostat FYX-051	Xanthine Oxidase Cytochrome P450	Metabolic Disease
Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC₅₀ value of 5.3 nM and a K_i value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment.

HY-N0814B

Phytic acid hexasodium Inositol hexaphosphate hexasodium	Endogenous Metabolite	Inflammation/Immunology Neurological Disease
Phytic acid (Inositol hexaphosphate) hexasodium is a phosphorus storage compound of seeds and cereal grains. Phytic acid hexasodium has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid hexasodium inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.

HY-106235

LB80317	HBV DNA/RNA Synthesis	Infection
LB80317 is an active metabolite of LB80380 and suppresses the DNA synthesis of HBV with an EC₅₀ of 0.5 μM. LB80317 has antiviral effect and has the potential for chronic hepatitis B treatment.

HY-W017163S

7-Methylxanthine-2,4,5,6-13C4, 1,3-15N2 (with variable 15N labeling at N9)	Endogenous Metabolite	Metabolic Disease
7-Methylxanthine-2,4,5,6-¹³C₄, 1,3-¹⁵N₂ (with variable ¹⁵N labeling at N₉) is the ¹³C and ¹⁵N labeled 7-Methylxanthine[1]. 7-Methylxanthine, a methyl derivative of xanthine, is one of the purine components in urinary calculi[2].

HY-14874S

Topiroxostat-d4 FYX-051-d₄	Xanthine Oxidase Cytochrome P450	Metabolic Disease
Topiroxostat-d₄ is deuterium labeled Topiroxostat. Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment[1][2].

HY-N0814

Phytic acid Inositol hexaphosphate	Xanthine Oxidase Endogenous Metabolite	Inflammation/Immunology Neurological Disease
Phytic acid (Inositol hexaphosphate) is a phosphorus storage compound of seeds and cereal grains. Phytic acid is known as a food inhibitor, which has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.

HY-142125

Broussochalcone A	Xanthine Oxidase Reactive Oxygen Species Apoptosis	Cancer Inflammation/Immunology
Broussochalcone A is an antioxidant and an inhibitor of Xanthine Oxidase (IC₅₀=2.21 μM), with free radical scavenging activity. Broussochalcone A inhibits iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (LPS) -activated macrophages. Broussochalcone A also induces Apoptosis of human renal carcinoma cells by increasing ROS levels and activating FOXO3 signaling pathways.

HY-N0814A

Phytic acid dodecasodium hydrate Inositol hexaphosphate dodecasodium hydrate	Xanthine Oxidase Endogenous Metabolite	Inflammation/Immunology Neurological Disease
Phytic acid (Inositol hexaphosphate) dodecasodium hydrate is a phosphorus storage compound of seeds and cereal grains. Phytic acid dodecasodium hydrate is known as a food inhibitor, which has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid dodecasodium hydrate inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.

HY-B0219A

Allopurinol sodium	Xanthine Oxidase	Cancer Infection Inflammation/Immunology Neurological Disease
Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC₅₀ value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect.

HY-B0219

Allopurinol	Xanthine Oxidase	Cancer Infection Inflammation/Immunology Neurological Disease
Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC₅₀ value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect.

HY-141508

Flazin	Xanthine Oxidase NO Synthase	Metabolic Disease Inflammation/Immunology Neurological Disease
Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO^-), with an IC₅₀ value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC₅₀ value of 71.99 μM for ONOO^-. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor.

HY-152696

6-O-Methylinosine	Nucleoside Antimetabolite/Analog	Others
6-O-Methylinosine is a hypoxanthine analogue. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.

HY-W039271

2-Chloro-6-methoxypurine riboside 2-Chloro-6-O-methyl-inosine	Nucleoside Antimetabolite/Analog	Cancer
2-Chloro-6-methoxypurine riboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.

HY-154393

2-Chloro-2'-deoxy-6-O-methylinosine	Nucleoside Antimetabolite/Analog	Cancer
2-Chloro-2'-deoxy-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.

HY-154017

2′-C-Methyl-6-O-methylinosine	Nucleoside Antimetabolite/Analog	Cancer
2′-C-Methyl-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.

HY-W392836

2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite	Nucleoside Antimetabolite/Analog	Cancer
2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.

HY-152678

6-Methoxypurine-9-β-D-5’(R)-C-methylriboside	Nucleoside Antimetabolite/Analog	Cancer
6-Methoxypurine-9-β-D-5’(R)-C-methylriboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.

HY-P1435A

NoxA1ds TFA	NADPH Oxidase
NoxA1ds TFA is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC₅₀=20 nM). NoxA1ds TFA exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. NoxA1ds TFA inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.

HY-W141392

2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite	Nucleoside Antimetabolite/Analog	Cancer
2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.

HY-147908

Adenosine receptor inhibitor 2	Adenosine Receptor	Inflammation/Immunology
Adenosine receptor inhibitor 2 (compound 14b) is a potent AR (adenosine receptor) inhibitor. Adenosine receptor inhibitor 2 shows dual affinity toward A₁/A_2A ARs with higher affinity for the A₁- than the A_2AAR. Adenosine receptor inhibitor 2 has K_i values of 52.2 nM for the A₁AR and 167 nM for the A_2AAR.

Cat. No.	Product Name	Type