2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite

Cat. No.: HY-W392836 Pureté: 98.0%: Fiche technique
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2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.

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2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite Chemical Structure

CAS No. : 128219-85-2

Size	Stock	Quantité
100 mg	En stock	Estimated Time of Arrival: December 31
250 mg	En stock	Estimated Time of Arrival: December 31
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Description	2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia^[1]^[2].
Masse moléculaire	784.84
Formule	C₄₁H₄₉N₆O₈P
CAS No.	128219-85-2
Appearance	Solid
Color	White to off-white
SMILES	COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@H]4O[C@@H](N5C=NC6=C5NC=NC6=O)[C@H](OC)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N
Livraison	Room temperature in continental US; may vary elsewhere.
Stockage	4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Pureté et documentation	Purity: 98.0% Select Batch: Fiche technique (275 KB) SDS (419 KB) COA (259 KB) HNMR (144 KB) LCMS (106 KB) Instruction de manipulation (2659 KB)
Références	[1]. Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107. [Content Brief] [2]. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50. [Content Brief]