128219-85-2
Chemical Structure
2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite
- CAS No.: 128219-85-2
- Formula:C41H49N6O8P
- Molecular Weight:784.84
IUPAC Name: 1-(3,5-dichlorophenyl)cyclopropane-1-carboxylic acid
InChIKey: PVFNTYBGWVZMCX-HLHZJIEZSA-N
SMILES: COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@H]4O[C@@H](N5C=NC6=C5NC=NC6=O)[C@H](OC)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N
Biological Activity: 2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].
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2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite | 98.0% | 2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia. | ||||||||||||||||||||
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- [1]. Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107. [Content Brief]
- [2]. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50. [Content Brief]
