Niraxostat
Based on 1 Customer Validation
Niraxostat (Y-700; Piraxostat) is an orally active xanthine oxidoreductase (XOR) inhibitor used in the study of hyperuricemia and other diseases in which XOR may be involved.
For research use only. We do not sell to patients.
- Purity: 98.54%
- CAS No.: 206884-98-2
- Formula: C16H17N3O3
- Molecular Weight:299.32
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Niraxostat (Y- 700; 1-10 mg/kg; oral; single dose) dose-dependently reduces plasma urate levels in oxonate-treated rats [1].
Niraxostat (Y-700 ; 0.3-3 mg/kg; Oral; Single dose) In normal rats, dose-dependently reduces urinary excretion of urate and allantoin while increasing excretion of hypoxanthine and xanthine [1].
Pharmacokinetic Analysis of Niraxostat (Y-700) in normal rats[1]
| Route | Dose (mg/kg) | tmax (h) | Cmax (μg/ml) | AUC0-∞ (μg/h/ml) | t1/2 (h) |
| PO | 0.3 | 0.5 | 0.43 | 2.07 | 5.0 |
| PO | 1 | 0.3 | 1.8 | 7.01 | 3.2 |
| PO | 3 | 0.5 | 6.49 | 30.31 | 2.7 |
| IV | 1 | / | 3.97 | 8.34 | 2.5 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 206884-98-2
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Appearance Solid
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Molecular Weight 299.32
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Formula C16H17N3O3
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Color White to off-white
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SMILES
O=C(C1=CN(C2=CC=C(OCC(C)(C)C)C(C#N)=C2)N=C1)O
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Synonyms
Y-700; Piraxostat
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 83.33 mg/mL (278.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3409 mL | 16.7045 mL | 33.4091 mL | 83.5226 mL |
| 5 mM | 0.6682 mL | 3.3409 mL | 6.6818 mL | 16.7045 mL | |
| 10 mM | 0.3341 mL | 1.6705 mL | 3.3409 mL | 8.3523 mL | |
| 15 mM | 0.2227 mL | 1.1136 mL | 2.2273 mL | 5.5682 mL | |
| 20 mM | 0.1670 mL | 0.8352 mL | 1.6705 mL | 4.1761 mL | |
| 25 mM | 0.1336 mL | 0.6682 mL | 1.3364 mL | 3.3409 mL | |
| 30 mM | 0.1114 mL | 0.5568 mL | 1.1136 mL | 2.7841 mL | |
| 40 mM | 0.0835 mL | 0.4176 mL | 0.8352 mL | 2.0881 mL | |
| 50 mM | 0.0668 mL | 0.3341 mL | 0.6682 mL | 1.6705 mL | |
| 60 mM | 0.0557 mL | 0.2784 mL | 0.5568 mL | 1.3920 mL | |
| 80 mM | 0.0418 mL | 0.2088 mL | 0.4176 mL | 1.0440 mL | |
| 100 mM | 0.0334 mL | 0.1670 mL | 0.3341 mL | 0.8352 mL |
Niraxostat Related Classifications
HY-14669 Related Classifications
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