Allopurinol sodium
Based on 12 publication(s) in Google Scholar
Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 17795-21-0
- Formula: C5H4N4NaO
- Molecular Weight:159.10
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Allopurinol sodium
More- Adv Sci (Weinh). 2024 Sep 3:e2400684. [Abstract]
- Cell Rep Med. 2024 Aug 20;5(8):101690. [Abstract]
- Mol Med. 2025 May 13;31(1):184. [Abstract]
- Drug Deliv Transl Res. 2025 Oct 29. [Abstract]
- J Ethnopharmacol. 2025 Jan 19:119365. [Abstract]
- Cell Rep Methods. 2023 Oct 23;3(10):100599. [Abstract]
- Commun Biol. 2022 Jul 22;5(1):726. [Abstract]
- Pharmaceuticals (Basel). 2023 Feb 27;16(3):361. [Abstract]
- Int J Mol Sci. 2025 Sep 16;26(18):8999. [Abstract]
- J Biol Chem. 2021 Oct;297(4):101166. [Abstract]
- Cytokine. 2023 Mar:163:156120. [Abstract]
- Biomed Pharmacother. 2024 Jun 15:177:116859. [Abstract]
Customer Validation & Images
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IHC
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WB
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Cell Imaging/Staining
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Histological Imaging/Staining
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RT-PCR
Biological Activity
Allopurinol sodium (0, 10, 100, 1000 µg/ml; 17 h) decreases the expression of HIF-1α and HIF-2α protein in HFF and HUVEC cells[5].
Allopurinol sodium (0, 10, 100, 1000 µg/ml; 24 h) reduces angiogenesis traits of HUVEC cells[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HFF, HUVEC cells
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Concentration:0, 10, 100, 1000 µg/ml
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Incubation Time:17 h
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Result:Reduced HIF-1α and HIF-2α protein expression in a dose dependent manner.
Allopurinol sodium (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:20-30 g, male Swiss Albino mice[3]
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Dosage:39 mg/kg
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Administration:P.o.; daily for 21 successive days
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Result:Reduced the immobility time in the FST with the immobility time of 129.8±10.5 s.
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Animal Model:30-40 g, male adult Swiss albino mice[4]
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Dosage:10, 50, 100, 200, 400 mg/kg
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Administration:I.p.
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Result:Produced dose-dependent anti-nociception in the tail-flick, hot-plate.
Chemical Information
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CAS No. 17795-21-0
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Appearance Solid
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Molecular Weight 159.10
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Formula C5H4N4NaO
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Color White to off-white
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SMILES
O=C1C2=C(NN=C2)N=CN1.[Na]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (12)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic-Comorbidities Related Signatures in Craniopharyngioma. [Abstract]2024 Sep 3:e2400684. PMID: 39225628
Allopurinol sodium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 3:e2400684. [Abstract]
Quantitative analyses of histopathological results reveal a notable increase in collagen volume fraction (9.95 ± 0.50) and oil red area fraction (10.06 ± 0.64) in CP mice treated with WD + Hx, meanwhile NAC (collagen volume fraction: 5.29 ± 0.60; oil red area fraction: 0.08 ± 0.01) and Allopurinol (Allo, 2 g/L in the drinking water and a Western diet for 8 weeks) treatment (collagen volume fraction: 4.63 ± 0.36; oil red area fraction: 0.06 ± 0.001) induced remarkable alleviation in parameters above.
Allopurinol sodium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 3:e2400684. [Abstract]
In the target organs (liver and brain cortex), Hx treatment suppressed the relative mRNA expression of critical enzymes in purine metabolism (HPRT, XOR, and PNP) as well as crucial players in anti‐oxidative system (Nrf2, SOD‐1, and CAT), meanwhile, NAC and Allopurinol (Allo, 2 g/L in the drinking water and a Western diet for 8 weeks) treatment induced significant upregulation in relative expression of these genes.
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Cell Rep Med
The SGLT2 inhibitor dapagliflozin ameliorates renal fibrosis in hyperuricemic nephropathy. [Abstract]2024 Aug 20;5(8):101690. PMID: 39168099 -
Mol Med
JAK2/STAT3/HMGCS2 signaling aggravates mitochondrial dysfunction and oxidative stress in hyperuricemia-induced cardiac dysfunction. [Abstract]2025 May 13;31(1):184. PMID: 40361044
Allopurinol sodium purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 May 13;31(1):184. [Abstract]
Allopurinol (10 mg/kg/day; oral gavage; once daily for 4 weeks) can significantly reduce the elevated IL-6 levels in the hearts of hyperuricemic mice.
Allopurinol sodium purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 May 13;31(1):184. [Abstract]
Allopurinol (10 mg/kg/day; oral gavage; once daily for 4 weeks) effectively reduced the phosphorylation of JAK2 and STAT3 and decreased the expression of HMGCS2 protein in the hearts of hyperuricemic mice.
Allopurinol sodium purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 May 13;31(1):184. [Abstract]
Representative transmission electron microscopy images of mitochondria in cardiomyocytes. Scale bar: 500 nm. Electron microscopy revealed severe mitochondrial damage in cardiomyocytes of hyperuricemic mice, which was normalized by treatment with Allopurinol (10 mg/kg/day; oral gavage; once daily for 4 weeks).
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Drug Deliv Transl Res
Leveraging quantum chemical properties in transfer learning for predicting blood-brain barrier permeability of drugs. [Abstract]2025 Oct 29. PMID: 41160380 -
J Ethnopharmacol
Polysaccharide extracted from Phellinus igniarius attenuated hyperuricemia by modulating bile acid metabolism and inhibiting uric acid synthesis in adenine/potassium oxonate-treated mice. [Abstract]2025 Jan 19:119365. PMID: 39837359 -
Cell Rep Methods
RECOVER identifies synergistic drug combinations in vitro through sequential model optimization. [Abstract]2023 Oct 23;3(10):100599. PMID: 37797618 -
Commun Biol
mTOR contributes to endothelium-dependent vasorelaxation by promoting eNOS expression and preventing eNOS uncoupling. [Abstract]2022 Jul 22;5(1):726. PMID: 35869262 -
Pharmaceuticals (Basel)
2023 Feb 27;16(3):361. PMID: 36986461 -
Int J Mol Sci
Ampelopsis japonica Extract Exhibited Significant Uric Acid-Lowering Effect by Downregulating URAT1/GLUT9 and Alleviates Inflammation Through TLR4/NF- κ B Pathway. [Abstract]2025 Sep 16;26(18):8999. PMID: 41009565 -
J Biol Chem
Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid. [Abstract]2021 Oct;297(4):101166. PMID: 34487763 -
Cytokine
Qinling liquid ameliorates renal immune inflammatory damage via activating autophagy through AMPK/Stat3 pathway in uric acid nephropathy. [Abstract]2023 Mar:163:156120. PMID: 36630870 -
Biomed Pharmacother
Aqueous extract of Phellinus igniarius ameliorates hyperuricemia and renal injury in adenine/potassium oxonate-treated mice. [Abstract]2024 Jun 15:177:116859. PMID: 38879892
Allopurinol sodium purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Jun 15:177:116859. [Abstract]
Allopurinol (5 mg/kg; p.o.; single dose) significantly reduces the mRNA levels of XOD in HUA mice.
Solvent & Solubility
H2O : 40 mg/mL (251.41 mM; ultrasonic and adjust pH to 12 with 1 M NaOH)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006;58(1):87-114. [Content Brief]
[2]. Pfaller MA, et al. Antileishmanial effect of allopurinol. Antimicrob Agents Chemother. 1974;5(5):469-472. [Content Brief]
[3]. Karve AV, et al. Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice. Indian J Pharmacol. 2013 May-Jun;45(3):244-7. [Content Brief]
[4]. Schmidt AP, et al. Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors. Br J Pharmacol. 2009 Jan;156(1):163-72. [Content Brief]
[5]. Sun Y, et al. Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia. PLoS One. 2015 Apr 1;10(4):e0123649. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.2854 mL | 31.4268 mL | 62.8535 mL | 157.1339 mL |
| 5 mM | 1.2571 mL | 6.2854 mL | 12.5707 mL | 31.4268 mL | |
| 10 mM | 0.6285 mL | 3.1427 mL | 6.2854 mL | 15.7134 mL | |
| 15 mM | 0.4190 mL | 2.0951 mL | 4.1902 mL | 10.4756 mL | |
| 20 mM | 0.3143 mL | 1.5713 mL | 3.1427 mL | 7.8567 mL | |
| 25 mM | 0.2514 mL | 1.2571 mL | 2.5141 mL | 6.2854 mL | |
| 30 mM | 0.2095 mL | 1.0476 mL | 2.0951 mL | 5.2378 mL | |
| 40 mM | 0.1571 mL | 0.7857 mL | 1.5713 mL | 3.9283 mL | |
| 50 mM | 0.1257 mL | 0.6285 mL | 1.2571 mL | 3.1427 mL | |
| 60 mM | 0.1048 mL | 0.5238 mL | 1.0476 mL | 2.6189 mL | |
| 80 mM | 0.0786 mL | 0.3928 mL | 0.7857 mL | 1.9642 mL | |
| 100 mM | 0.0629 mL | 0.3143 mL | 0.6285 mL | 1.5713 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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