Allopurinol sodium

Name: Allopurinol sodium
Brand: MedChemExpress
SKU: HY-B0219A
Rating: 4.5 (4 reviews)

Cat. No.: HY-B0219A Purity: 99.76%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC₅₀ value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect.

For research use only. We do not sell to patients.

Allopurinol sodium Chemical Structure

CAS No. : 17795-21-0

Size	Price	Stock	Quantity
10 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Allopurinol sodium:

Allopurinol In-stock

4 Publications Citing Use of MCE Allopurinol sodium

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Allopurinol sodium (0, 10, 100, 1000 µg/ml; 17 h) decreases the expression of HIF-1α and HIF-2α protein in HFF and HUVEC cells^[5].
Allopurinol sodium (0, 10, 100, 1000 µg/ml; 24 h) reduces angiogenesis traits of HUVEC cells^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[5]

Cell Line:	HFF, HUVEC cells
Concentration:	0, 10, 100, 1000 µg/ml
Incubation Time:	17 h
Result:	Reduced HIF-1α and HIF-2α protein expression in a dose dependent manner.

In Vivo

Allopurinol sodium (39 mg/kg; p.o.; daily for 21 successive days) shows anti-depressant activity in mouse^[3].
Allopurinol sodium (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	20-30 g, male Swiss Albino mice^[3]
Dosage:	39 mg/kg
Administration:	P.o.; daily for 21 successive days
Result:	Reduced the immobility time in the FST with the immobility time of 129.8±10.5 s.

Animal Model:	30-40 g, male adult Swiss albino mice^[4]
Dosage:	10, 50, 100, 200, 400 mg/kg
Administration:	I.p.
Result:	Produced dose-dependent anti-nociception in the tail-flick, hot-plate.

Clinical Trial

Molecular Weight

159.10

Formula

C₅H₄N₄NaO

CAS No.

17795-21-0

Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(NN=C2)N=CN1.[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (314.27 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.2854 mL	31.4268 mL	62.8535 mL
5 mM	1.2571 mL	6.2854 mL	12.5707 mL
10 mM	0.6285 mL	3.1427 mL	6.2854 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.76%

Select Batch:

Data Sheet (279 KB) SDS (251 KB)

COA (253 KB) HNMR (223 KB) RP-HPLC (224 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006;58(1):87-114. [Content Brief]

[2]. Pfaller MA, et al. Antileishmanial effect of allopurinol. Antimicrob Agents Chemother. 1974;5(5):469-472. [Content Brief]

[3]. Karve AV, et al. Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice. Indian J Pharmacol. 2013 May-Jun;45(3):244-7. [Content Brief]

[4]. Schmidt AP, et al. Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors. Br J Pharmacol. 2009 Jan;156(1):163-72. [Content Brief]

[5]. Sun Y, et al. Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia. PLoS One. 2015 Apr 1;10(4):e0123649. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.2854 mL	31.4268 mL	62.8535 mL	157.1339 mL
	5 mM	1.2571 mL	6.2854 mL	12.5707 mL	31.4268 mL
	10 mM	0.6285 mL	3.1427 mL	6.2854 mL	15.7134 mL
	15 mM	0.4190 mL	2.0951 mL	4.1902 mL	10.4756 mL
	20 mM	0.3143 mL	1.5713 mL	3.1427 mL	7.8567 mL
	25 mM	0.2514 mL	1.2571 mL	2.5141 mL	6.2854 mL
	30 mM	0.2095 mL	1.0476 mL	2.0951 mL	5.2378 mL
	40 mM	0.1571 mL	0.7857 mL	1.5713 mL	3.9283 mL
	50 mM	0.1257 mL	0.6285 mL	1.2571 mL	3.1427 mL
	60 mM	0.1048 mL	0.5238 mL	1.0476 mL	2.6189 mL
	80 mM	0.0786 mL	0.3928 mL	0.7857 mL	1.9642 mL
	100 mM	0.0629 mL	0.3143 mL	0.6285 mL	1.5713 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.