Allopurinol sodium

Name: Allopurinol sodium
Brand: MedChemExpress
SKU: HY-B0219A
Rating: 5.0 (12 reviews)

Cat. No.: HY-B0219A Purity: 99.90%: Data Sheet
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Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC₅₀ value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect.

For research use only. We do not sell to patients.

CAS No. : 17795-21-0

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 12 publication(s) in Google Scholar

Other Forms of Allopurinol sodium:

Allopurinol In-stock

12 Publications Citing Use of MCE Allopurinol sodium

Histological Imaging/Staining

IHC

RT-PCR

Cell Imaging/Staining

: Allopurinol sodium purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 May 13;31(1):184. [Abstract]; Allopurinol (10 mg/kg/day; oral gavage; once daily for 4 weeks) can significantly reduce the elevated IL-6 levels in the hearts of hyperuricemic mice.

: Allopurinol sodium purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 May 13;31(1):184. [Abstract]; Allopurinol (10 mg/kg/day; oral gavage; once daily for 4 weeks) effectively reduced the phosphorylation of JAK2 and STAT3 and decreased the expression of HMGCS2 protein in the hearts of hyperuricemic mice.

: Allopurinol sodium purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 May 13;31(1):184. [Abstract]; Representative transmission electron microscopy images of mitochondria in cardiomyocytes. Scale bar: 500 nm. Electron microscopy revealed severe mitochondrial damage in cardiomyocytes of hyperuricemic mice, which was normalized by treatment with Allopurinol (10 mg/kg/day; oral gavage; once daily for 4 weeks).

: Allopurinol sodium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 3:e2400684. [Abstract]; Quantitative analyses of histopathological results reveal a notable increase in collagen volume fraction (9.95 ± 0.50) and oil red area fraction (10.06 ± 0.64) in CP mice treated with WD + Hx, meanwhile NAC (collagen volume fraction: 5.29 ± 0.60; oil red area fraction: 0.08 ± 0.01) and Allopurinol (Allo, 2 g/L in the drinking water and a Western diet for 8 weeks) treatment (collagen volume fraction: 4.63 ± 0.36; oil red area fraction: 0.06 ± 0.001) induced remarkable alleviation in parameters above.

: Allopurinol sodium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 3:e2400684. [Abstract]; In the target organs (liver and brain cortex), Hx treatment suppressed the relative mRNA expression of critical enzymes in purine metabolism (HPRT, XOR, and PNP) as well as crucial players in anti‐oxidative system (Nrf2, SOD‐1, and CAT), meanwhile, NAC and Allopurinol (Allo, 2 g/L in the drinking water and a Western diet for 8 weeks) treatment induced significant upregulation in relative expression of these genes.

: Allopurinol sodium purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Jun 15:177:116859. [Abstract]; Allopurinol (5 mg/kg; p.o.; single dose) significantly reduces the mRNA levels of XOD in HUA mice.

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Allopurinol sodium (0, 10, 100, 1000 µg/ml; 17 h) decreases the expression of HIF-1α and HIF-2α protein in HFF and HUVEC cells^[5].
Allopurinol sodium (0, 10, 100, 1000 µg/ml; 24 h) reduces angiogenesis traits of HUVEC cells^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[5]

Cell Line:	HFF, HUVEC cells
Concentration:	0, 10, 100, 1000 µg/ml
Incubation Time:	17 h
Result:	Reduced HIF-1α and HIF-2α protein expression in a dose dependent manner.

In Vivo

Allopurinol sodium (39 mg/kg; p.o.; daily for 21 successive days) shows anti-depressant activity in mouse^[3].
Allopurinol sodium (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	20-30 g, male Swiss Albino mice^[3]
Dosage:	39 mg/kg
Administration:	P.o.; daily for 21 successive days
Result:	Reduced the immobility time in the FST with the immobility time of 129.8±10.5 s.

Animal Model:	30-40 g, male adult Swiss albino mice^[4]
Dosage:	10, 50, 100, 200, 400 mg/kg
Administration:	I.p.
Result:	Produced dose-dependent anti-nociception in the tail-flick, hot-plate.

Molecular Weight

159.10

Formula

C₅H₄N₄NaO

CAS No.

17795-21-0

Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(NN=C2)N=CN1.[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 40 mg/mL (251.41 mM; ultrasonic and adjust pH to 12 with 1 M NaOH)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.2854 mL	31.4268 mL	62.8535 mL
5 mM	1.2571 mL	6.2854 mL	12.5707 mL
10 mM	0.6285 mL	3.1427 mL	6.2854 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (279 KB) SDS (393 KB)

COA (253 KB) HNMR (226 KB) RP-HPLC (205 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006;58(1):87-114. [Content Brief]

[2]. Pfaller MA, et al. Antileishmanial effect of allopurinol. Antimicrob Agents Chemother. 1974;5(5):469-472. [Content Brief]

[3]. Karve AV, et al. Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice. Indian J Pharmacol. 2013 May-Jun;45(3):244-7. [Content Brief]

[4]. Schmidt AP, et al. Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors. Br J Pharmacol. 2009 Jan;156(1):163-72. [Content Brief]

[5]. Sun Y, et al. Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia. PLoS One. 2015 Apr 1;10(4):e0123649. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.2854 mL	31.4268 mL	62.8535 mL	157.1339 mL
	5 mM	1.2571 mL	6.2854 mL	12.5707 mL	31.4268 mL
	10 mM	0.6285 mL	3.1427 mL	6.2854 mL	15.7134 mL
	15 mM	0.4190 mL	2.0951 mL	4.1902 mL	10.4756 mL
	20 mM	0.3143 mL	1.5713 mL	3.1427 mL	7.8567 mL
	25 mM	0.2514 mL	1.2571 mL	2.5141 mL	6.2854 mL
	30 mM	0.2095 mL	1.0476 mL	2.0951 mL	5.2378 mL
	40 mM	0.1571 mL	0.7857 mL	1.5713 mL	3.9283 mL
	50 mM	0.1257 mL	0.6285 mL	1.2571 mL	3.1427 mL
	60 mM	0.1048 mL	0.5238 mL	1.0476 mL	2.6189 mL
	80 mM	0.0786 mL	0.3928 mL	0.7857 mL	1.9642 mL
	100 mM	0.0629 mL	0.3143 mL	0.6285 mL	1.5713 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.