7-Methylxanthine

Name: 7-Methylxanthine
Brand: MedChemExpress
SKU: HY-W017163
Rating: 4.5 (0 reviews)

Cat. No.: HY-W017163 Purity: 99.94%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

7-Methylxanthine is an orally active methyl derivative of xanthine and a non-selective adenosine receptor antagonist. 7-Methylxanthine is also one of the purine components of human urinary calculi. 7-Methylxanthine has anti-myopia activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

7-Methylxanthine 화학구조

CAS No. : 552-62-5

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of 7-Methylxanthine:

7-Methylxanthine-d3₃ In-stock
7-Methylxanthine-2,4,5,6-¹³C₄, 1,3-¹⁵N₂ (with variable ¹⁵N labeling at N₉) 견적 받기
7-Methylxanthine (Standard) 견적 받기

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Endogenous Metabolite Isoform Specific Products:

View All Isoforms

Human Endogenous Metabolite Microbial Metabolite

View All Adenosine Receptor Isoform Specific Products:

View All Isoforms

Adenosine A₁ receptor (A₁R) Adenosine A_2A receptor (A_2AR) Adenosine A_2B receptor (A_2BR) Adenosine A₃ receptor (A₃R)

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

Human Endogenous Metabolite

In Vivo

7-Methylxanthine (100 mg/kg; oral administration; twice daily; starting from 3 weeks of age until 147±4 days) can alter the emmetropizing responses in infant macaques^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Macaca mulatta aged 2-3 weeks old were reared with -3D or +3D spectacle over their treated eyes and zero-powered lenses over their fellow eyes^[2]
Dosage:	100 mg/kg
Administration:	Oral administration, twice daily, from 24±2 days of age until 147±4 days of age
Result:	Eliminated the consistent myopic anisometropia normally produced by -3D of imposed monocular defocus. Caused compensating hyperopic anisometropias. Changed the course of emmetropization in both the treated and fellow eyes of the lens-reared monkeys, resulting in more hyperopic refractive errors. Led to a reduction in vitreous chamber elongation and an increase in choroidal thickness.

Clinical Trial

분자량

166.14

화학식

C₆H₆N₄O₂

CAS No.

552-62-5

Appearance

Solid

Color

White to light brown

SMILES

CN1C=NC2=C1C(=O)NC(=O)N2

Structure Classification

Others

Initial Source

Microorganisms

Endogenous metabolite

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

용액&용해도

In Vitro:

DMSO : 3.33 mg/mL (20.04 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.0190 mL	30.0951 mL	60.1902 mL
5 mM	1.2038 mL	6.0190 mL	12.0380 mL
10 mM	0.6019 mL	3.0095 mL	6.0190 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 8.33 mg/mL (50.14 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.94%

Select Batch:

Data Sheet (276 KB) SDS (392 KB)

COA (251 KB) HNMR (152 KB) RP-HPLC (205 KB) MS (229 KB)

Handling Instructions (2659 KB)

References

[1]. Caubet MS, et al. Determination of urinary 13C-caffeine metabolites by liquid chromatography-mass spectrometry: the use of metabolic ratios to assess CYP1A2 activity. J Pharm Biomed Anal. 2004 Feb 4;34(2):379-89. [Content Brief]

[2]. Hung LF, et al. The Adenosine Receptor Antagonist, 7-Methylxanthine, Alters Emmetropizing Responses in Infant Macaques. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):472-486. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.0190 mL	30.0951 mL	60.1902 mL	150.4755 mL
	5 mM	1.2038 mL	6.0190 mL	12.0380 mL	30.0951 mL
	10 mM	0.6019 mL	3.0095 mL	6.0190 mL	15.0476 mL
	15 mM	0.4013 mL	2.0063 mL	4.0127 mL	10.0317 mL
	20 mM	0.3010 mL	1.5048 mL	3.0095 mL	7.5238 mL