552-62-5
552-62-5
Chemical Structure
7-Methylxanthine
- CAS No.: 552-62-5
- Formula:C6H6N4O2
- Molecular Weight:166.14
IUPAC Name: 7-methyl-7H-purine-2,6-diol
InChIKey: PFWLFWPASULGAN-UHFFFAOYSA-N
SMILES: CN1C=NC2=C1C(=O)NC(=O)N2
Biological Activity: 7-Methylxanthine is an orally active methyl derivative of xanthine and a non-selective adenosine receptor antagonist. 7-Methylxanthine is also one of the purine components of human urinary calculi. 7-Methylxanthine has anti-myopia activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
7-Methylxanthine | 99.94% | 7-Methylxanthine is an orally active methyl derivative of xanthine and a non-selective adenosine receptor antagonist. 7-Methylxanthine is also one of the purine components of human urinary calculi. 7-Methylxanthine has anti-myopia activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
7-Methylxanthine (Standard) | ≥98% | 7-Methylxanthine (Standard) is the analytical standard of 7-Methylxanthine. This product is intended for research and analytical applications. 7-Methylxanthine is an orally active methyl derivative of xanthine and a non-selective adenosine receptor antagonist. 7-Methylxanthine is also one of the purine components of human urinary calculi. 7-Methylxanthine has anti-myopia activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
7-Methylxanthine-d33 | 99.31% | 7-Methylxanthine-d3 is deuterium labeled 7-Methylxanthine. 7-Methylxanthine, a methyl derivative of xanthine, is one of the purine components in urinary calculi. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
7-Methylguanine (Standard) | ≥98% | 7-Methylguanine (Standard) is the analytical standard of 7-Methylguanine (HY-113352). This product is intended for research and analytical applications. 7-Methylguanine is an orally active and competitive PARP-1 inhibitor with a Ki value of 61 μM. 7-Methylguanine is a metabolite of nucleic acids. 7-Methylguanine has anticancer activity against uterine sarcoma and colon adenocarcinoma. 7-Methylguanine is used as a probe for protein-DNA interactions. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
7-Methylguanine-d3 | 7-Methylguanine-d3 is the deuterium labeled 7-Methylguanine. 7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
7-Methyl-3-methyluric acid-d3 | 7-Methyl-3-methyluric acid-d3 is the deuterium labeled 7-Methyl-3-methyluric acid. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
3-Methylxanthine | 99.45% | 3-Methylxanthine is a blood-brain barrier-permeable cyclic GMP phosphodiesterase inhibitor, with an IC50 of 920 μM against guinea pig cyclic GMP phosphodiesterase. 3-Methylxanthine relaxes the spontaneous tension of isolated guinea pig tracheal smooth muscle preparations. Through a DRD1-dependent pathway, 3-Methylxanthine upregulates the expression of γH2AX and activated caspase-3, downregulates the expression of Bcl-2, and enhances Cisplatin-induced apoptosis (apoptosis) in ovarian cancer cells both in vitro and in vivo. 3-Methylxanthine induces clonic convulsions in the central nervous system. 3-Methylxanthine is the major metabolite of Theophylline (HY-B0809). 3-Methylxanthine can be used in studies related to ovarian cancer and neurotoxic convulsions. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Theobromine | 99.74% | Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Theobromine-d6 | 98.0% | Theobromine-d6 is the deuterium labeled Theobromine. Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Theobromine-d3 | 99.78% | Theobromine-d3 is the deuterium labeled Theobromine. Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
1-Methylxanthine-13C,d3 | 1-Methylxanthine-13C,d3 is the 13C- and deuterium labeled 1-Methylxanthine. 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
1-Methylxanthine-13C4,15N3 | 1-Methylxanthine-13C4,15N3 is the 13C-labeled and 15N-labeled 1-Methylxanthine. 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
1-Methylxanthine-d3 | 1-Methylxanthine-d3 is deuterated labeled 1-Methylxanthine (HY-W008449). 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
1-Methyluric acid-d3 | 96.02% | 1-Methyluric acid-d3 is the deuterium labeled 1-Methyluric acid (HY-W010031). 1-Methyluric acid acts on the urinary bladder mucosa and increases the blood glucose, insulin, triglyceride, and cholesterol levels. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Paraxanthine (Standard) | 99.77% | Paraxanthine (Standard) is the analytical standard of Paraxanthine. This product is intended for research and analytical applications. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Paraxanthine-d6 | 98.92% | Paraxanthine-d6 is the deuterium labeled Paraxanthine. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Paraxanthine-13C4,15N3 | 99.80% | Paraxanthine-13C4,15N3 is the 13C-labeled and 15N-labeled Paraxanthine. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Xanthine (Standard) | 99.09% | Xanthine (Standard) is the analytical standard of Xanthine. This product is intended for research and analytical applications. Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation. In Vitro: A number of stimulants are derived from Xanthine including caffeine and theobromine. Xanthine is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Xanthine-13C,15N2 | 95.64% | Xanthine-13C,15N2 is a 15N-labeled and 13C-labled Xanthine (HY-W017389). Xanthine is a plant alkaloid with mild stimulant activity of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Xanthine-15N2 | 99.35% | Xanthine-15N2 is a 15N-labeled Xanthine (HY-W017389). Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
7-Methyl-1-(methyl-d3)-3,7-dihydro-1H-purine-2,6-dione | 7-Methyl-1-(methyl-d3)-3,7-dihydro-1H-purine-2,6-dione is deuterium-labeled 7-Methyl-1-(methyl-d3)-3,7-dihydro-1H-purine-2,6-dione. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Caubet MS, et al. Determination of urinary 13C-caffeine metabolites by liquid chromatography-mass spectrometry: the use of metabolic ratios to assess CYP1A2 activity. J Pharm Biomed Anal. 2004 Feb 4;34(2):379-89. [Content Brief]
- [2]. Hung LF, et al. The Adenosine Receptor Antagonist, 7-Methylxanthine, Alters Emmetropizing Responses in Infant Macaques. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):472-486. [Content Brief]
