Paraxanthine-13C4,15N3
Based on 1 Customer Validation
Paraxanthine-13C4,15N3 is the 13C-labeled and 15N-labeled Paraxanthine. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.
For research use only. We do not sell to patients.
- Purity: 99.80%
- CAS No.: 1173018-79-5
- Formula: C313C4H8N15N3O2
- Molecular Weight:187.11
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1173018-79-5
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Unlabeled Cas 611-59-6
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Appearance Solid
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Molecular Weight 187.11
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Formula C313C4H8N15N3O2
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Color White to light yellow
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SMILES
CN1C=[15N][13C]([15NH][13C]2=O)=[13C]1[13C]([15N]2C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : ≥ 30 mg/mL (160.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
DMF : ≥ 20 mg/mL (106.89 mM)
Ethanol : ≥ 0.5 mg/mL (2.67 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Guerreiro S, et al. Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels. Mol Pharmacol. 2008 Oct;74(4):980-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMF / DMSO | 1 mM | 5.3444 mL | 26.7222 mL | 53.4445 mL | 133.6112 mL |
| DMF / DMSO | 5 mM | 1.0689 mL | 5.3444 mL | 10.6889 mL | 26.7222 mL |
| 10 mM | 0.5344 mL | 2.6722 mL | 5.3444 mL | 13.3611 mL | |
| 15 mM | 0.3563 mL | 1.7815 mL | 3.5630 mL | 8.9074 mL | |
| 20 mM | 0.2672 mL | 1.3361 mL | 2.6722 mL | 6.6806 mL | |
| 25 mM | 0.2138 mL | 1.0689 mL | 2.1378 mL | 5.3444 mL | |
| 30 mM | 0.1781 mL | 0.8907 mL | 1.7815 mL | 4.4537 mL | |
| 40 mM | 0.1336 mL | 0.6681 mL | 1.3361 mL | 3.3403 mL | |
| 50 mM | 0.1069 mL | 0.5344 mL | 1.0689 mL | 2.6722 mL | |
| 60 mM | 0.0891 mL | 0.4454 mL | 0.8907 mL | 2.2269 mL | |
| 80 mM | 0.0668 mL | 0.3340 mL | 0.6681 mL | 1.6701 mL | |
| 100 mM | 0.0534 mL | 0.2672 mL | 0.5344 mL | 1.3361 mL |
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