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Art. -Nr.: HY-W014993S

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1,3-Dimethyluric acid-¹³C₄,¹⁵N₃

1,3-Dimethyluric acid-¹³C₄,¹⁵N₃ is the ¹⁵N and ¹³C-labeled 1,3-Dimethyluric acid (HY-W014993). 1,3-Dimethyluric acid is a major metabolite of Theophylline (HY-B0809) in vivo. 1,3-Dimethyluric acid is an inhibitor of human organic anion transporter 1 (hOAT1) with an IC₅₀ of 9.2 μM. 1,3-Dimethyluric acid inhibits hOAT1-mediated substrate uptake and transport through competitive binding. 1,3-Dimethyluric acid is also a component of urinary calculi. 1,3-Dimethyluric acid can be used in research on urolithiasis.

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CAS. Nr.: 1173019-16-3
Formel: C₃¹³C₄H₈N¹⁵N₃O₃
Molecular Weight:203.11

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

1,3-Dimethyluric acid-¹³C₄,¹⁵N₃ Chemical Structure

CAS. Nr.: 1173019-16-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]^[2]

Human Endogenous Metabolite

hOAT1

9.2 μM (IC₅₀)

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Anwendung

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS. Nr. 1173019-16-3
Molecular Weight 203.11
Formel C₃¹³C₄H₈N¹⁵N₃O₃
SMILES

O=[13C]1[13C]2=[13C]([15NH]C(N2)=O)[15N]([13C]([15N]1C)=O)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Choi HD, et al. Effects of water deprivation on the pharmacokinetics of theophylline and one of its metabolites, 1,3-dimethyluric acid, after intravenous and oral administration of aminophylline to rats. Biopharmaceutics & drug disposition. 2007 Nov;28(8):445-54.

[2]. Sugawara M, et al. Structure-affinity relationship in the interactions of human organic anion transporter 1 with caffeine, theophylline, theobromine and their metabolites. Biochim Biophys Acta. 2005 Aug 15;1714(2):85-92.

[3]. Yoon Y, et al. Associations between CYP2E1 promoter polymorphisms and plasma 1,3-dimethyluric acid/theophylline ratios. European journal of clinical pharmacology. 2006 Aug;62(8):627-31.

[4]. Yu SY, et al. Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation. The Journal of pharmacy and pharmacology. 2002 Dec;54(12):1687-92.

[5]. Kuroda Y, et al. Age-Associated Theophylline Metabolic Activity Corresponds to the Ratio of 1,3-Dimethyluric Acid to Theophylline in Mice. Biological & pharmaceutical bulletin. 2019;42(8):1423-1427. [Content Brief]

[6]. Kim YC, et al. Pharmacokinetics of theophylline in diabetes mellitus rats: induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2005 Sep;26(1):114-23.

[7]. Tang-Liu DD, et al. Nonlinear theophylline elimination. Clin Pharmacol Ther. 1982 Mar;31(3):358-69.

[8]. Kuh HJ, et al. Nonlinear renal excretion of theophylline and its metabolites, 1-methyluric acid and 1,3-dimethyluric acid, in rats. Archives of pharmacal research. 1994 Apr;17(2):124-30. [Content Brief]

[9]. Safranow K, et al. Simultaneous determination of 16 purine derivatives in urinary calculi by gradient reversed-phase high-performance liquid chromatography with UV detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 May 25;819(2):229-35.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

1,3-Dimethyluric acid-¹³C₄,¹⁵N₃

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1,3-Dimethyluric acid-13C4,15N3

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