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Cat. No.: HY-W014993S1

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1,3-Dimethyluric acid-d₃

1,3-Dimethyluric acid-d₃ is the deuterated-labeled 1,3-Dimethyluric acid (HY-W014993). 1,3-Dimethyluric acid is a major metabolite of Theophylline (HY-B0809) in vivo. 1,3-Dimethyluric acid is an inhibitor of human organic anion transporter 1 (hOAT1) with an IC₅₀ of 9.2 μM. 1,3-Dimethyluric acid inhibits hOAT1-mediated substrate uptake and transport through competitive binding. 1,3-Dimethyluric acid is also a component of urinary calculi. 1,3-Dimethyluric acid can be used in research on urolithiasis.

For research use only. We do not sell to patients.

Formula: C₇H₅D₃N₄O₃
Molecular Weight:199.18

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (284 KB)

1,3-Dimethyluric acid-d₃ Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Application
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

^[1]^[2]

Human Endogenous Metabolite

hOAT1

9.2 μM (IC₅₀)

All Endogenous Metabolite Isoforms :

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 944-73-0
Molecular Weight 199.18
Formula C₇H₅D₃N₄O₃
SMILES

O=C(N1C([2H])([2H])[2H])N(C)C2=C(NC(N2)=O)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Choi HD, et al. Effects of water deprivation on the pharmacokinetics of theophylline and one of its metabolites, 1,3-dimethyluric acid, after intravenous and oral administration of aminophylline to rats. Biopharmaceutics & drug disposition. 2007 Nov;28(8):445-54.

[2]. Sugawara M, et al. Structure-affinity relationship in the interactions of human organic anion transporter 1 with caffeine, theophylline, theobromine and their metabolites. Biochim Biophys Acta. 2005 Aug 15;1714(2):85-92.

[3]. Yoon Y, et al. Associations between CYP2E1 promoter polymorphisms and plasma 1,3-dimethyluric acid/theophylline ratios. European journal of clinical pharmacology. 2006 Aug;62(8):627-31.

[4]. Yu SY, et al. Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation. The Journal of pharmacy and pharmacology. 2002 Dec;54(12):1687-92.

[5]. Kuroda Y, et al. Age-Associated Theophylline Metabolic Activity Corresponds to the Ratio of 1,3-Dimethyluric Acid to Theophylline in Mice. Biological & pharmaceutical bulletin. 2019;42(8):1423-1427.

[6]. Kim YC, et al. Pharmacokinetics of theophylline in diabetes mellitus rats: induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2005 Sep;26(1):114-23.

[7]. Tang-Liu DD, et al. Nonlinear theophylline elimination. Clin Pharmacol Ther. 1982 Mar;31(3):358-69.

[8]. Kuh HJ, et al. Nonlinear renal excretion of theophylline and its metabolites, 1-methyluric acid and 1,3-dimethyluric acid, in rats. Archives of pharmacal research. 1994 Apr;17(2):124-30.

[9]. Safranow K, et al. Simultaneous determination of 16 purine derivatives in urinary calculi by gradient reversed-phase high-performance liquid chromatography with UV detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 May 25;819(2):229-35.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
Purity & Documentation
References

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1,3-Dimethyluric acid-d3

All Endogenous Metabolite Isoforms

Biological Activity

Description

IC50 & Target

Application

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

1,3-Dimethyluric acid-d3 Related Classifications

HY-W014993S1 Related Classifications

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