1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite


Cat. No.: HY-W016498
Handling Instructions

Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.

For research use only. We do not sell to patients.

Paraxanthine Chemical Structure

Paraxanthine Chemical Structure

CAS No. : 611-59-6

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References


Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.

IC50 & Target[1]

Ryanodine Receptor Channels


Human Endogenous Metabolite


In Vitro

When Paraxanthine (PX) is applied to the cultures for a prolonged period, the number of TH+neurons is augmented in a dose-dependent manner. The effect of Paraxanthine, already significant at 100 μM, increases gradually and remains optimal between 800 and 1000 μM, at 10 DIV. Counts of TH+neurons performs at different stages of maturation of the cultures indicate that Paraxanthine most likely prevents DA cell loss. GDNF, a prototypical trophic factor for DA neurons, is only slightly more effective than 800 μM Paraxanthine in rescuing DA neurons after 10 and 16 DIV when used at an optimal concentration of 20 ng/mL. About 80% of caffeine is N3-demethylated to form Paraxanthine, Unlike Paraxanthine, caffeine is poorly effective in protecting DA neurons from death For example, at a concentration of 800 μM, caffeine produces only a modest 40% increase in the number of TH+ cells at 10 DIV, whereas the same concentration of Paraxanthine optimally promotes DA cell survival (169% increase)[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5503 mL 27.7516 mL 55.5031 mL
5 mM 1.1101 mL 5.5503 mL 11.1006 mL
10 mM 0.5550 mL 2.7752 mL 5.5503 mL
*Please refer to the solubility information to select the appropriate solvent.
Molecular Weight









Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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Cat. No.: HY-W016498