1. GPCR/G Protein
  2. Adenosine Receptor

Adenosine Receptor

Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as NF-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.

Adenosine Receptor Related Products (24):

Cat. No. Product Name Effect Purity
  • HY-10889
    Preladenant Antagonist
    Preladenant is a potent competitive antagonist of the human A2A receptor (Ki=1.1 nM) and has >1000-fold selectivity over all other adenosine receptors.
  • HY-10857
    Vipadenant Antagonist
    Vipadenant is an adenosine receptor antagonist, with Ki of 1.3 nM and 68 nM for A2A and A1, respectively.
  • HY-10995
    Tozadenant Antagonist
    Tozadenant is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A.
  • HY-13201A
    CGS 21680 Hydrochloride Agonist
    CGS 21680 Hcl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor.
  • HY-19532
    ZM241385 Antagonist
    ZM 241385 is a novel non-xanthine adenosine receptor antagonist with selectivity for the A2a receptor subtype.
  • HY-N0586
    Norisoboldine Agonist
    Norisoboldine is an isoquinoline alkaloid which acts as an AhR agonist, and enhances the function of the adenosine A1 receptor.
  • HY-12365
    2-Cl-IB-MECA Agonist
    2-Cl-IB-MECA is a selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively.
  • HY-10888
    Istradefylline Antagonist
    Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease.
  • HY-14917
    Capadenoson Agonist
    Capadenoson is a selective agonist of adenosine-A1 receptor.
  • HY-19533
    SCH 58261 Antagonist
    SCH 58261 is the adenosine A2A receptor competitive antagonist. Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively.
  • HY-A0168
    Regadenoson Agonist
    Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator that is commonly used in pharmacologic stress testing.
  • HY-B0809
    Theophylline Inhibitor
    Theophylline is a methylated xanthine derivative; competitive nonselective phosphodiesterase inhibitor and nonselective adenosine receptor antagonist.
  • HY-13591
    IB-MECA Agonist
    IB-MECA is an agonist of the adenosine A3 receptor with EC50 values of 0.11 μM.
  • HY-18687
    N6-[2-(4-Aminophenyl)ethyl]adenosine Agonist
    N6-[2-(4-Aminophenyl)ethyl]adenosine is a potent, non-selective A3 adenosine receptor agonist.
  • HY-B0153A
    Ticlopidine hydrochloride Inhibitor
    Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 μM.
  • HY-18978
    GR79236 Agonist
    GR79236 is a highly potent and selective adenosine A1 receptor agonist (Ki = 3.1 nM) that has analgesic and anti-inflammatory actions in humans and animals.
  • HY-13201
    CGS 21680 Agonist
    CGS 21680 is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor.
  • HY-B0128
    Diphylline Antagonist
    Dyphylline acts as an adenosine receptor antagonist and phosphodiesterase inhibitor, which is used in the treatment of respiratory disorders.
  • HY-18939
    N6-Cyclohexyladenosine Agonist
    N6-Cyclohexyladenosine is a selective A1 receptor agonist (EC50 = 8.2 nM).
  • HY-100032
    PD 117519 Agonist
    PD 117519 is an adenosine agonist.