1. GPCR/G Protein
  2. Adenosine Receptor

Adenosine Receptor

Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as NF-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.

Adenosine Receptor Related Products (48):

Cat. No. Product Name Effect Purity
  • HY-10889
    Preladenant Antagonist 99.08%
    Preladenant is a potent and competitive antagonist of the human adenosine A2A receptor with a Ki of 1.1 nM and has over 1000-fold selectivity over other adenosine receptors.
  • HY-13201A
    CGS 21680 Hydrochloride Agonist 99.70%
    CGS 21680 Hydrochloride is a selective adenosine A2A receptor agonist with a Ki of 27 nM.
  • HY-19532
    ZM241385 Antagonist 98.55%
    ZM 241385 is a selective and high affinity A2A adenosine receptor antagonist.
  • HY-B0809
    Theophylline Inhibitor 99.94%
    Theophylline is a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator.
  • HY-19533
    SCH 58261 Antagonist 99.38%
    SCH 58261 is the adenosine A2A receptor competitive antagonist. Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively.
  • HY-112840
    ST3932 Antagonist
    ST3932 is a metabolite of ST1535, acts as an antagonist of adenosine A2A receptor, with Kis of 8 nM and 33 nM for A2A and A1 receptors, respectively.
  • HY-112502
    MethADP Inhibitor
    MethADP is a specific CD73 inhibitor.
  • HY-10857
    Vipadenant Antagonist 98.28%
    Vipadenant is an adenosine receptor antagonist, with Kis of 1.3 nM and 68 nM for A2A and A1, respectively.
  • HY-101978
    CPI-444 Inhibitor 99.85%
    CPI-444 is a potent and selective inhibitor of A2A receptor (A2AR) induces antitumor responses.
  • HY-10888
    Istradefylline Antagonist 99.42%
    Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease.
  • HY-10995
    Tozadenant Antagonist 98.06%
    Tozadenant is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A.
  • HY-14917
    Capadenoson Agonist 98.43%
    Capadenoson is a selective agonist of adenosine-A1 receptor.
  • HY-12365
    Namodenoson Agonist 99.51%
    2-Cl-IB-MECA is a selective A3 adenosine receptor agonist (Ki = 0.33 nM).
  • HY-101980
    AZD4635 Inhibitor 99.79%
    AZD4635 is a novel adenosine 2A receptor (A2AR) inhibitor with a Ki of 1.7 nM.
  • HY-103173
    5'-N-Ethylcarboxamidoadenosine Agonist 99.86%
    NECA is a nonselective adenosine receptor agonist.
  • HY-A0168
    Regadenoson Agonist >98.0%
    Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator that is commonly used in pharmacologic stress testing.
  • HY-B0153A
    Ticlopidine hydrochloride Inhibitor 99.99%
    Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 μM.
  • HY-100747
    PSB-12379 Inhibitor 99.99%
    PSB-12379 is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).
  • HY-18939
    N6-Cyclohexyladenosine Agonist 99.98%
    N6-Cyclohexyladenosine is a selective A1 receptor agonist (EC50 = 8.2 nM).
  • HY-13591
    IB-MECA Agonist 98.97%
    IB-MECA is an agonist of the adenosine A3 receptor with EC50 values of 0.11 μM.
Isoform Specific Products

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