1. Signaling Pathways
  2. GPCR/G Protein
  3. Adenosine Receptor

Adenosine Receptor

Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as NF-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.

Adenosine Receptor Related Products (63):

Cat. No. Product Name Effect Purity
  • HY-101978
    CPI-444 Antagonist 99.94%
    CPI-444 is a potent, oral and selective A2A receptor (A2AR) antagonist, which induces antitumor responses.
  • HY-13201A
    CGS 21680 Hydrochloride Agonist 99.70%
    CGS 21680 Hydrochloride is a selective adenosine A2A receptor agonist with a Ki of 27 nM.
  • HY-19533
    SCH 58261 Antagonist 99.65%
    SCH 58261 is a potent, selective and competitive antagonist of adenosine A2A receptor with an IC50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively.
  • HY-19532
    ZM241385 Antagonist 98.55%
    ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM.
  • HY-B0809
    Theophylline Inhibitor 99.94%
    Theophylline is a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator.
  • HY-14858
    Derenofylline Antagonist >99.0%
    Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats.
  • HY-129393
    A2aR/A2bR antagonist-1 Antagonist 98.31%
    A2aR/A2bR antagonist-1 is an orally bioavailable, selective dual adenosine receptor (A2aR/A2bR) antagonist with immunomodulatory activity.
  • HY-110037
    MRS-3777 hemioxalate Antagonist
    MRS-3777 hemioxalate is a selective adenosine A3 receptor antagonist.
  • HY-103173
    5'-N-Ethylcarboxamidoadenosine Agonist 99.86%
    5'-N-Ethylcarboxamidoadenosine (NECA) is a nonselective adenosine receptor agonist.
  • HY-10888
    Istradefylline Antagonist 99.42%
    Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease.
  • HY-101980
    AZD4635 Antagonist 99.79%
    AZD4635 is a potent and selective, orally available adenosine A2A receptor (A2AR) antagonist. AZD4635 binds to human A2AR with a Ki of 1.7 nM and with > 30-fold selectivity over other adenosine receptors.
  • HY-10889
    Preladenant Antagonist 98.04%
    Preladenant is a potent and competitive antagonist of the human adenosine A2A receptor with a Ki of 1.1 nM and has over 1000-fold selectivity over other adenosine receptors.
  • HY-12365
    Namodenoson Agonist 99.71%
    Namodenoson (CF-102) is a selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively.
  • HY-14917
    Capadenoson Agonist 98.43%
    Capadenoson is a selective agonist of adenosine-A1 receptor.
  • HY-B0153A
    Ticlopidine hydrochloride Inhibitor 99.99%
    Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 μM.
  • HY-18939
    N6-Cyclohexyladenosine Agonist 99.98%
    N6-Cyclohexyladenosine is a selective A1 receptor agonist (EC50 = 8.2 nM).
  • HY-10995
    Tozadenant Antagonist 98.06%
    Tozadenant is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A.
  • HY-A0168
    Regadenoson Agonist 99.59%
    Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator that is commonly used in pharmacologic stress testing.
  • HY-13591
    Piclidenoson Agonist 99.42%
    Piclidenoson (IB-MECA; CF-101) is an agonist of the adenosine A3 receptor with EC50 values of 0.11 μM.
  • HY-111767
    BAY-545 Inhibitor
    BAY-545 is a potent and selective A2B adenosine receptor antagonist, with an IC50 of 59 nM. BAY-545 also exhibits IC50s of 66, 400, 280 nM for human, mouse, rat A2B adenosine receptor in cells, respectively, and a Ki of 97 nM for human A2B adenosine receptor, with more selectivity over A1, A2A, and A3 adenosine receptor.
Isoform Specific Products

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