Signaling Pathway

Adenosine Receptor

Adenosine Receptor

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Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as nuclear factor (NF)-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.

Adenosine Receptor Inhibitors & Modulators (25)

Product Name Catalog No. Brief Description
2-Cl-IB-MECA

HY-12365

2-Cl-IB-MECA is a selective A3 adenosine receptor agonist (Ki = 0.33 nM).

A2AR-agonist-1

HY-18776

A2AR-agonist-1 is a potent A2AR and ENT1 agonist with Ki of  4.39 and 3.47 for A2AR and ENT1.

AB-MECA

HY-19365

AB-MECA is a high affinity A3 adenosine receptor agonist, has high affinity for recombinant A1 and A3 receptors.

Capadenoson

HY-14917

Capadenoson (BAY 68-4986) is a new adenosine A1 receptor agonist.

CGS 21680

HY-13201

CGS 21680 is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor.

CGS 21680 Hydrochloride

HY-13201A

CGS 21680 Hcl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor.

Diphylline

HY-B0128

Dyphylline acts as an adenosine receptor antagonist and phosphodiesterase inhibitor, which is used in the treatment of respiratory disorders.

GR79236

HY-18978

GR79236 is a highly potent and selective adenosine A1 receptor agonist (Ki = 3.1 nM) that has analgesic and anti-inflammatory actions in humans and animals.

IB-MECA

HY-13591

IB-MECA is an agonist of the adenosine A3 receptor with EC50 values of 0.11 μM.

Istradefylline

HY-10888

Istradefylline(KW6002) is a very potent, selective and orally active adenosine A2A receptor antagonist(Ki=2.2 nM) in experimental models of Parkinson's disease.

LUF6000

HY-13236

LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR).

N-[(4-Aminophenyl)methyl]adenosine

HY-100130

N-[(4-Aminophenyl)methyl]adenosine is a adenosine receptor inhibitor, with Ki of 29 nM for Rat ecto-5′-Nucleotidase.

N6-Cyclohexyladenosine

HY-18939

N6-Cyclohexyladenosine is a selective A1 receptor agonist (EC50 = 8.2 nM).

N6-[2-(4-Aminophenyl)ethyl]adenosine

HY-18687

N6-[2-(4-Aminophenyl)ethyl]adenosine is a potent, non-selective A3 adenosine receptor agonist.

Norisoboldine

HY-N0586

is an isoquinoline alkaloid which acts as an AhR agonist, and enhances the function of the adenosine A1 receptor.

PD 117519

HY-100032

PD 117519  is an adenosine agonist.

Preladenant

HY-10889

Preladenant (SCH 420814) is a potent and selective antagonist at the adenosine A2A receptor.

Regadenoson

HY-A0168

Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator that is commonly used in pharmacologic stress testing.

SCH 58261

HY-19533

SCH 58261 is the adenosine A2A receptor competitive antagonist.

Theophylline

HY-B0809

Theophylline is a methylated xanthine derivative; competitive nonselective phosphodiesterase inhibitor and nonselective adenosine receptor antagonist.