1. GPCR/G Protein
  2. Adenosine Receptor
  3. SCH 58261

SCH 58261 

Cat. No.: HY-19533 Purity: 99.38%
Handling Instructions

SCH 58261 is a potent, selective and competitive antagonist of adenosine A2A receptor with an IC50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively.

For research use only. We do not sell to patients.

SCH 58261 Chemical Structure

SCH 58261 Chemical Structure

CAS No. : 160098-96-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
Estimated Time of Arrival: December 31
10 mg USD 168 In-stock
Estimated Time of Arrival: December 31
50 mg USD 648 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1128 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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  • References

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Description

SCH 58261 is a potent, selective and competitive antagonist of adenosine A2A receptor with an IC50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively[1][2][3].

IC50 & Target

IC50: 15 nM (A2A receptor)[2]

In Vitro

SCH 58261 (0 nM–10 µM; 7 days) decreases cell viability in a concentration-dependent in the NSCLC cell line H1975[4].
SCH58261 (25 μM; 72 hours) can inhibit the growth of CAF cells[5].

Cell Viability Assay[4]

Cell Line: H1975 cells
Concentration: 10 nM-10 µM
Incubation Time: 7 days
Result: Produced a concentration-dependent decrease in H1975 cell growth.

Cell Proliferation Assay[5]

Cell Line: CAF cells
Concentration: 25 μM
Incubation Time: 72 hours
Result: Inhibit the growth of CAF1 and CAF2 cells.
In Vivo

SCH 58261 (2 mg/kg; i.p.; daily; for 20 days) causes a decrease in the tumor burden in a NSCLC mouse model[5].
SCH 58261 (5 mg/kg; i.p.; 3 times; every 3 hours; 10 minutes before haloperidol) partially decreases the haloperidol-induced catalepsy and the increase in the PENK mRNA expression in both dorsolateral and ventrolateral parts of the striatum at all three examined levels[6].
SCH 58261 diminishes the parkinsonian-like muscle rigidity and potentiates the effect of L-DOPA in rat model[7].

Animal Model: 4‒6 weeks old athymic nude mice (NCI) with PC9 cells xenograft[5]
Dosage: 2 mg/kg
Administration: Intraperitoneal injection; daily; for 20 days
Result: Decreased tumor growth.
Molecular Weight

345.36

Formula

C₁₈H₁₅N₇O

CAS No.

160098-96-4

SMILES

NC1=NC(N(CCC2=CC=CC=C2)N=C3)=C3C4=NC(C5=CC=CO5)=NN14

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (98.45 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8955 mL 14.4776 mL 28.9553 mL
5 mM 0.5791 mL 2.8955 mL 5.7911 mL
10 mM 0.2896 mL 1.4478 mL 2.8955 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.38%

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Product Name:
SCH 58261
Cat. No.:
HY-19533
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