1. GPCR/G Protein
    Apoptosis
  2. Adenosine Receptor
    Apoptosis
  3. Piclidenoson

Piclidenoson (Synonyms: IB-MECA; CF-101)

Cat. No.: HY-13591 Purity: 99.42%
Handling Instructions

Piclidenoson (IB-MECA; CF-101) is an agonist of the adenosine A3 receptor with EC50 values of 0.11 μM.

For research use only. We do not sell to patients.

Piclidenoson Chemical Structure

Piclidenoson Chemical Structure

CAS No. : 152918-18-8

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10 mM * 1 mL in DMSO USD 135 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
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10 mg USD 200 In-stock
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25 mg USD 400 In-stock
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50 mg USD 660 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Piclidenoson (IB-MECA; CF-101) is an agonist of the adenosine A3 receptor with EC50 values of 0.11 μM. IC50 value: 0.11 μM (EC50) [3] Target: adenosine A3 receptor in vitro: Piclidenoson has been shown to play important roles in cell proliferation and apoptosis in a variety of cancer cell lines. The Piclidenoson was capable of decreasing intracellular cyclic adenosine monophosphate (cAMP) that was the reason for the presence of functional A3 adenosine receptor on the cell lines. Piclidenoson significantly reduced cell viability in a dose-dependent manner. Piclidenoson, an A3AR agonist, inhibits the growth of different cancer cell types like melanoma, colon, breast, leukemia, and prostate Piclidenoson was able to inhibit forskolin-stimulated cAMP levels with an EC50 value of 0.82 μM in OVCAR-3 cells. Piclidenoson was able to inhibit forskolin-stimulated cAMP levels with an EC50 value of 1.2 μM in Caov-4 cells. in vivo: Administrations of single intraperitoneal doses of either Piclidenoson 0.5 h post-irradiation resulted in statistically significant increases of MST in comparison with the control irradiated mice.[2]

Clinical Trial
Molecular Weight

510.29

Formula

C₁₈H₁₉IN₆O₄

CAS No.

152918-18-8

SMILES

O[[email protected]]1[[email protected]](N2C=NC3=C(NCC4=CC=CC(I)=C4)N=CN=C23)O[[email protected]](C(NC)=O)[[email protected]]1O

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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 45 mg/mL (88.19 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9597 mL 9.7983 mL 19.5967 mL
5 mM 0.3919 mL 1.9597 mL 3.9193 mL
10 mM 0.1960 mL 0.9798 mL 1.9597 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.90 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.90 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.90 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PiclidenosonIB-MECACF-101CF101CF 101Adenosine ReceptorApoptosisP1 receptorInhibitorinhibitorinhibit

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Piclidenoson
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HY-13591
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