1. GPCR/G Protein
  2. Adenosine Receptor

IB-MECA (Synonyms: Piclidenoson; CF-101)

Cat. No.: HY-13591 Purity: 98.97%
Data Sheet SDS Handling Instructions

IB-MECA is an agonist of the adenosine A3 receptor with EC50 values of 0.11 μM.

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IB-MECA Chemical Structure

IB-MECA Chemical Structure

CAS No. : 152918-18-8

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10 mM * 1 mL in DMSO $157 In-stock
5 mg $140 In-stock
10 mg $240 In-stock
25 mg $520 In-stock
50 mg $940 In-stock
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Description

IB-MECA is an agonist of the adenosine A3 receptor with EC50 values of 0.11 μM. IC50 value: 0.11 μM (EC50) [3] Target: adenosine A3 receptor in vitro: IB-MECA has been shown to play important roles in cell proliferation and apoptosis in a variety of cancer cell lines. The IB-MECA was capable of decreasing intracellular cyclic adenosine monophosphate (cAMP) that was the reason for the presence of functional A3 adenosine receptor on the cell lines. IB-MECA significantly reduced cell viability in a dose-dependent manner. IB-MECA, an A3AR agonist, inhibits the growth of different cancer cell types like melanoma, colon, breast, leukemia, and prostate IB-MECA was able to inhibit forskolin-stimulated cAMP levels with an EC50 value of 0.82 μM in OVCAR-3 cells. IB-MECA was able to inhibit forskolin-stimulated cAMP levels with an EC50 value of 1.2 μM in Caov-4 cells. in vivo: Administrations of single intraperitoneal doses of either IB-MECA 0.5 h post-irradiation resulted in statistically significant increases of MST in comparison with the control irradiated mice.[2]

References
M.Wt

510.29

Formula

C₁₈H₁₉IN₆O₄

CAS No.

152918-18-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 45 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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IB-MECA
Cat. No.:
HY-13591
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