3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor

  • J Med Chem. 2003 Jan 30;46(3):353-5. doi: 10.1021/jm0255724.
Michael P DeNinno  1 ,  Hiroko Masamune ,  Lois K Chenard ,  Kenneth J DiRico ,  Cynthia Eller ,  John B Etienne ,  Jeanene E Tickner ,  Scott P Kennedy ,  Delvin R Knight ,  Jimmy Kong ,  Joseph J Oleynek ,  W Ross Tracey ,  Roger J Hill
Affiliations
  • 1. PGRD Groton Laboratories, Pfizer Inc., Groton, Connecticut 06340, USA. [email protected]
PMID: 12540233 DOI: 10.1021/jm0255724
Abstract

Selective adenosine A(3) agonists have potential utility for the prevention of perioperative myocardial ischemic injury. Herein, we report on the discovery and synthesis of compound 7. This amino nucleoside agonist possesses unprecedented levels of selectivity for the human adenosine A(3) receptor.