1. GPCR/G Protein
  2. Adenosine Receptor
  3. PSB-603

PSB-603 

Cat. No.: HY-103166
Handling Instructions

PSB-603 is a potent and selective adenosine A2B receptor antagonist exhibiting a Ki value of 0.553 nM at the human A2B receptor and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM.

For research use only. We do not sell to patients.

PSB-603 Chemical Structure

PSB-603 Chemical Structure

CAS No. : 1092351-10-4

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Description

PSB-603 is a potent and selective adenosine A2B receptor antagonist exhibiting a Ki value of 0.553 nM at the human A2B receptor and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM[1].

In Vitro

PSB-603 inhibits human A2B receptor in Jurkat T cells with an IC50 of 1.13 nM[1].
PSB-603 inhibits human, rat, and mouse A2B receptors with Ki values of 0.553, 0.355, and 0.265 nM, respectively[2].
PSB-603 (100 nM; 24 hours) antagonizes NECA (an adenosine receptor agonist; 1µM) inhibited interferon-γ and stimulated interleukin-6 production[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: Peripheral T cells
Concentration: 100 nM
Incubation Time: 24 hours
Result: Significantly inhibited NECA stimulated IL-6 release ≈3-fold.
In Vivo

PSB-603 shows anti-inflammatory effect in local and systemic inflammation models. PSB-603 (5 mg/kg b.w. ip) significantly reduces inflammation in two mice models of inflammation (local and systemic). PSB-603 significantly decreases levels of the inflammatory cytokines IL-6, TNF-α and of ROS in the inflamed paw and reduces inflammation of the peritoneum by significantly decreasing the infiltration of leukocytes[4]. PSB-603 is administered as suspensions in 1 % Tween 80[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Albino Swiss mice, CD-1, weighing 25-30 g[4]
Dosage: 1, 5 or 10 mg/kg
Administration: Administered intraperitoneally (ip), prior to carrageenan injection
Result: Carrageenan-induced edema model. The increase in paw oedema was significantly inhibited in all groups receiving PSB-603. The dose of 5 mg/kg turned out to be the most active.
Molecular Weight

529.01

Formula

C₂₄H₂₅ClN₆O₄S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
PSB-603
Cat. No.:
HY-103166
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