1. GPCR/G Protein
  2. Adenosine Receptor
  3. PSB-603

PSB-603 

Cat. No.: HY-103166
COA Handling Instructions

PSB-603 is a potent and highly selective A2B adenosine receptor antagonist exhibiting a Ki value of 0.553 nM and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM.

For research use only. We do not sell to patients.

PSB-603 Chemical Structure

PSB-603 Chemical Structure

CAS No. : 1092351-10-4

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Description

PSB-603 is a potent and highly selective A2B adenosine receptor antagonist exhibiting a Ki value of 0.553 nM and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM[1].

In Vitro

PSB-603 is a potent and selective adenosine A2B receptor antagonist exhibiting a Ki value of 0.553 nM at the human A2B receptor and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: Peripheral T cells
Concentration: 100 nM
Incubation Time: 24 hours
Result: Significantly inhibited NECA stimulated IL-6 release ≈3-fold.
In Vivo

PSB-603 shows anti-inflammatory effect in local and systemic inflammation models. PSB-603 (5 mg/kg b.w. ip) significantly reduces inflammation in two mice models of inflammation (local and systemic). PSB-603 significantly decreases levels of the inflammatory cytokines IL-6, TNF-α and of ROS in the inflamed paw and reduces inflammation of the peritoneum by significantly decreasing the infiltration of leukocytes[4]. PSB-603 is administered as suspensions in 1 % Tween 80[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Albino Swiss mice, CD-1, weighing 25-30 g[4]
Dosage: 1, 5 or 10 mg/kg
Administration: Administered intraperitoneally (ip), prior to carrageenan injection
Result: Carrageenan-induced edema model. The increase in paw oedema was significantly inhibited in all groups receiving PSB-603. The dose of 5 mg/kg turned out to be the most active.
Molecular Weight

529.01

Formula

C24H25ClN6O4S

CAS No.
SMILES

O=C(N1CCC)NC2=C(N=C(C3=CC=C(S(=O)(N4CCN(C5=CC=C(Cl)C=C5)CC4)=O)C=C3)N2)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PSB-603
Cat. No.:
HY-103166
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