1. GPCR/G Protein
  2. Adenosine Receptor
  3. DPCPX

DPCPX (Synonyms: PD 116948)

Cat. No.: HY-100937 Purity: 98.25%
Handling Instructions

DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes.

For research use only. We do not sell to patients.

DPCPX Chemical Structure

DPCPX Chemical Structure

CAS No. : 102146-07-6

Size Price Stock Quantity
25 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 105 In-stock
Estimated Time of Arrival: December 31
100 mg USD 155 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes[1][2][3].

IC50 & Target

Ki: 0.46 nM (3H-CHA binding to A1 receptors in rat whole brain membranes); 340 nM (3H-NECA binding to A2 receptors in rat striatal membranes)[2].

In Vivo

DPCPX (PD 116948) ( 0.1, 0.3 and 1.0 mg/kg i.v. ) produces significant dose-related increases (P<0.05) in urine volume and in urinary sodium, potassium and chloride excretion[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

304.39

Formula

C₁₆H₂₄N₄O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (41.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2853 mL 16.4263 mL 32.8526 mL
5 mM 0.6571 mL 3.2853 mL 6.5705 mL
10 mM 0.3285 mL 1.6426 mL 3.2853 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (4.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
DPCPX
Cat. No.:
HY-100937
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