1. GPCR/G Protein
  2. Adenosine Receptor
  3. DPCPX

DPCPX (Synonyms: PD 116948)

Cat. No.: HY-100937
Handling Instructions

DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes.

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DPCPX Chemical Structure

DPCPX Chemical Structure

CAS No. : 102146-07-6

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Description

DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes[1][2][3].

IC50 & Target

Ki: 0.46 nM (3H-CHA binding to A1 receptors in rat whole brain membranes); 340 nM (3H-NECA binding to A2 receptors in rat striatal membranes)[2].

In Vivo

DPCPX (PD 116948) ( 0.1, 0.3 and 1.0 mg/kg i.v. ) produces significant dose-related increases (P<0.05) in urine volume and in urinary sodium, potassium and chloride excretion[3].

Molecular Weight

304.39

Formula

C₁₆H₂₄N₄O₂

CAS No.

102146-07-6

SMILES

O=C(N1CCC)N(CCC)C2=C(N=C(C3CCCC3)N2)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

DPCPXPD 116948PD116948PD-116948Adenosine ReceptorP1 receptorInhibitorinhibitorinhibit

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