102146-07-6
102146-07-6
Chemical Structure
DPCPX
Synonym(s): PD 116948
- CAS No.: 102146-07-6
- Formula:C16H24N4O2
- Molecular Weight:304.39
IUPAC Name: 8-cyclopentyl-1,3-dipropyl-3,9-dihydro-1H-purine-2,6-dione
InChIKey: FFBDFADSZUINTG-UHFFFAOYSA-N
SMILES: O=C(N1CCC)N(CCC)C2=C(N=C(C3CCCC3)N2)C1=O
Biological Activity: DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes[1][2][3].
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DPCPX | 99.96% | DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes. | ||||||||||||||||||||
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DPCPX (Standard) | ≥98% | DPCPX (Standard) is the analytical standard of DPCPX. This product is intended for research and analytical applications. DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes. | ||||||||||||||||||||
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DPCPX-d4 | DPCPX-d4 (PD 116948-d4) is deuterium-labeled DPCPX (HY-100937). | |||||||||||||||||||||
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References
- [1]. S J Haleen, et al. PD 116,948, a Highly Selective A1 Adenosine Receptor Antagonist. Life Sci. 1987 Feb 9;40(6):555-61. [Content Brief]
- [2]. R F Bruns, et al. Binding of the A1-selective Adenosine Antagonist 8-cyclopentyl-1,3-dipropylxanthine to Rat Brain Membranes. Naunyn Schmiedebergs Arch Pharmacol. 1987 Jan;335(1):59-63. [Content Brief]
- [3]. POSTER COMMUNICATIONS Part II. Br J Pharmacol. 1989 Jul; 97(Suppl): 496P–535P.
Keywords
